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. 2020 Sep;16(25):1921-1930.
doi: 10.2217/fon-2020-0371. Epub 2020 Jun 17.

V体育ios版 - FBXW7γ is a tumor-suppressive and prognosis-related FBXW7 transcript isoform in ovarian serous cystadenocarcinoma

Zhou Xu  1 , Lin Zhuang  1 , Xiaoyin Wang  1 , Qianrong Li  1 , Yan Sang  1 , Jiao Xu  1
Affiliations

FBXW7γ is a tumor-suppressive and prognosis-related FBXW7 transcript isoform in ovarian serous cystadenocarcinoma

Zhou Xu et al. Future Oncol. 2020 Sep.

Abstract

Aim: To explore FBXW7 protein-coding transcript isoform (α, β and γ) expression, their functions and prognostic value in ovarian serous cystadenocarcinoma (OSC). Materials & methods: FBXW7 transcript data were collected from The Cancer Genome Atlas and the Genotype-Tissue Expression project. IOSE, A2780 and SKOV3 cells were used for in vitro and in vivo studies. Results: FBXW7α and FBXW7γ are dominant protein-coding transcripts that were downregulated in OSC. FBXW7γ overexpression reduced the protein expression of c-Myc, Notch1 and Yap1 and suppressed OSC cell growth in vitro and in vivo VSports手机版. FBXW7γ expression was an independent indicator of longer disease-specific survival (HR: 0. 588; 95% CI: 0. 449-0. 770) and progression-free survival (HR: 0. 708; 95% CI: 0. 562-0. 892). Conclusion: FBXW7γ is a tumor-suppressive and might be the only prognosis-related FBXW7 transcript in OSC. .

Keywords: ENST00000296555; FBXW7; ovarian serous cystadenocarcinoma; prognosis V体育安卓版. .

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