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Review
. 2020 Dec;1874(2):188419.
doi: 10.1016/j.bbcan.2020.188419. Epub 2020 Aug 19.

"VSports注册入口" Resistin: An inflammatory cytokine with multi-faceted roles in cancer

Sarabjeet Kour Sudan  1 , Sachin Kumar Deshmukh  1 , Teja Poosarla  2 , Nicolette Paolaungthong Holliday  3 , Donna Lynn Dyess  4 , Ajay Pratap Singh  5 , Seema Singh  6
Affiliations
Review

Resistin: An inflammatory cytokine with multi-faceted roles in cancer (VSports手机版)

Sarabjeet Kour Sudan et al. Biochim Biophys Acta Rev Cancer. 2020 Dec.

Abstract

Systemic and organ-confined inflammation has been associated with cancer development and progression. Resistin, initially described as an adipocyte-derived cytokine in mice, is mostly expressed by the macrophages in humans. It has potent pro-inflammatory properties, and its elevated serum levels are detected in cancer patients. Aberrant expression of resistin receptors is also reported in several malignancies and associated with aggressive clinicopathological features. Several lines of evidence demonstrate that resistin, acting through its different receptors, promotes tumor growth, metastasis, and chemoresistance by influencing a variety of cellular phenotypes as well as by modulating the tumor microenvironment VSports手机版. Racially disparate expression of resistin has also attracted much interest, considering prevalent cancer health disparities. This review discusses the aberrant expression of resistin and its receptors, its diverse downstream signaling and impact on tumor growth, metastasis, angiogenesis, and therapy resistance to support its clinical exploitation in biomarker and therapeutic development. .

Keywords: Cancer; Cytokine; Inflammation; Resistin; Tumor microenvironment V体育安卓版. .

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Conflict of interest statement

Declaration of Competing Interest

The authors have no conflicts of interest to declare.

Declaration of interests

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures (VSports在线直播)

Figure 1.
Figure 1.
Structure of human resistin: Cartoon view of trimeric structure of resistin showing C-terminal globular domain containing antiparallel β-sheets and N-terminal α-helical domain linked by a flexible neck domain. The structure was predicted using the SWIS-MODEL program (https://swissmodel.expasy.org) [37] and drawn using PyMoL software.
Figure 2.
Figure 2.. Resistin signaling pathways in cancer.
Resistin binding to the transmembrane Toll-like receptor 4 (TLR4) and adenylyl cyclase-associated protein 1 (CAP1) receptors activates several signaling pathways leading to the cancer cell proliferation, invasion, migration, angiogenesis, apoptosis inhibition, and therapy resistance. Akt: Protein Kinase B; cAMP: Cyclic adenosine 3′,5′-monophosphate; EGFR: Epidermal growth factor receptor; ERK: extracellular-signal-regulated kinase; IRAK: Interleukin-1 receptor-associated kinase; IRF: Interferon Regulatory Factor; JNK: c-Jun N-terminal kinase; MAPK: Mitogen-activated protein kinase; mTOR: mammalian target of rapamycin; MyD88: Myeloid differentiation primary response 88; NF-κβ: nuclear factor κβ; PKA: Protein kinase A; PKC: Protein kinase C; PI3K: phosphoinositide 3-kinase; p70 S6K: 70-kDa ribosomal protein S6 kinase; ROR1: Receptor Tyrosine Kinase Like Orphan Receptor; SP-1: specificity protein-1(transcription factor); SRC: Proto-oncogene tyrosine-protein kinase; STAT 3: transducer and activator of transcription 3; TIRAP: TIR Domain Containing Adaptor Protein; TRAF6:TNF receptor-associated factor 6; TRAM: TRIF-related adaptor molecule; TRIF: TIR-domain-containing adapter-inducing interferon-β.
Figure 3.
Figure 3.. Role of resistin in cancer.
Inflammatory cytokine ‘resistin’ influence the pathobiology of cancer by inducing invasion, metastasis, epithelial to mesenchymal transition and stemness, angiogenesis, therapy resistance, and regulating cell cycle progression and apoptosis.
See this image and copyright information in PMC

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