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Review
. 2020 Mar 10;17(1):10.
doi: 10.1186/s12981-020-00267-2.

Metformin effect on gut microbiota: insights for HIV-related inflammation

Jing Ouyang  1   2   3 , Stéphane Isnard  2   3 , John Lin  2   3 , Brandon Fombuena  2   3   4 , André Marette  5   6 , Bertrand Routy  7   8 , Yaokai Chen  9 , Jean-Pierre Routy  10   11   12
Affiliations
Review

V体育安卓版 - Metformin effect on gut microbiota: insights for HIV-related inflammation

Jing Ouyang et al. AIDS Res Ther. .

V体育2025版 - Abstract

The gut microbiota is emerging as a prominent player in maintaining health through several metabolic and immune pathways. Dysregulation of gut microbiota composition, also known as dysbiosis, is involved in the clinical outcome of diabetes, inflammatory bowel diseases, cancer, aging and HIV infection VSports手机版. Gut dysbiosis and inflammation persist in people living with HIV (PLWH) despite receiving antiretroviral therapy, further contributing to non-AIDS comorbidities. Metformin, a widely used antidiabetic agent, has been found to benefit microbiota composition, promote gut barrier integrity and reduce inflammation in human and animal models of diabetes. Inspired by the effect of metformin on diabetes-related gut dysbiosis, we herein critically review the relevance of metformin to control inflammation in PLWH. Metformin may improve gut microbiota composition, in turn reducing inflammation and risk of non-AIDS comorbidities. This review will pave the way towards innovative strategies to counteract dysregulated microbiota and improve the lives of PLWH. .

Keywords: Gut permeability; HIV; Inflammation; Metformin; Microbiota V体育安卓版. .

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V体育官网入口 - Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Potential effects of metformin in non-diabetic PLWH
See this image and copyright information in PMC

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