日
 Skip to main page content (VSports)
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site VSports app下载. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2020 Mar 15:391:114900.
doi: 10.1016/j.taap.2020.114900. Epub 2020 Feb 19.

Leucovorin ameliorated methotrexate induced intestinal toxicity via modulation of the gut microbiota (VSports最新版本)

Xinyi Huang  1 , Qing Fang  1 , Tai Rao  1 , Luping Zhou  1 , Xiangchang Zeng  1 , Zhirong Tan  1 , Lulu Chen  2 , Dongsheng Ouyang  3
Affiliations

"V体育2025版" Leucovorin ameliorated methotrexate induced intestinal toxicity via modulation of the gut microbiota

Xinyi Huang et al. Toxicol Appl Pharmacol. .

V体育官网入口 - Abstract

Methotrexate (MTX) is a widely used therapeutic agent for the treatment of cancer and autoimmune diseases. However, its efficacy is often limited by adverse effects, such as intestinal toxicity. Although treatment with leucovorin (LV) is the most common method to reduce the toxic effects of MTX, it may also compromise the therapeutic effects of MTX. The gut microbiome has been reported to be associated with the intestinal toxicity of MTX. In this study, the intestinal damage of MTX was ameliorated by treatment with LV. Moreover, the population, diversity, and principal components of the gut microbiota in MTX-treated mice were restored by treatment with LV. The only element of the gut microbiota that was significantly changed after treatment with LV was Bifidobacterium, and supplementation with Bifidobacterium longum ameliorated MTX-induced intestinal damage. In conclusion, our results suggest that the balance and the composition of gut microbiota have an important role in the LV-mediated protection against MTX-induced intestinal toxicity VSports手机版. This work provides foundation of data in support of a new potential mechanism for the prevention of MTX-induced intestinal toxicity. .

Keywords: Bifidobacteria; Gut microbiota; Intestinal toxicity; Leucovorin; Methotrexate. V体育安卓版.

PubMed Disclaimer

Conflict of interest statement

Declaration of Competing Interest The authors declare that there are no conflicts of interest.

Publication types

VSports注册入口 - MeSH terms

LinkOut - more resources