Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

Marc Rigau^{1

2

3}, Simone Ostrouska^{4

5}, Thomas S Fulford¹, Darryl N Johnson^{1

3}, Katherine Woods^{4

5

6}, Zheng Ruan^{1

3}, Hamish E G McWilliam^{1

7}, Christopher Hudson⁶, Candani Tutuka^{4

5}, Adam K Wheatley^{1

8}, Stephen J Kent^{1

8}, Jose A Villadangos^{1

7}, Bhupinder Pal^{4

5}, Christian Kurts², Jason Simmonds⁹, Matthias Pelzing⁹, Andrew D Nash⁹, Andrew Hammet⁹, Anne M Verhagen⁹, Gino Vairo⁹, Eugene Maraskovsky⁹, Con Panousis⁹, Nicholas A Gherardin¹, Jonathan Cebon^{4

5

6

10

11}, Dale I Godfrey^#^{12

3}, Andreas Behren^#^{13

5

6

10}, Adam P Uldrich^#^{12

3}

Affiliations

¹ Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia.
² University of Bonn, Bonn, Germany.
³ Australian Research Council Centre of Excellence for Advanced Molecular Imaging at the University of Melbourne, Victoria 3010, Australia.
⁴ Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia.
⁵ School of Cancer Medicine, La Trobe University, Heidelberg, Victoria 3084, Australia.
⁶ Ludwig Institute for Cancer Research, Melbourne -Austin Branch, Victoria 3084, Australia.
⁷ Department of Biochemistry and Molecular Biology at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
⁸ Australian Research Council Centre of Excellence for Convergent Bio-Nano Science and Technology at the University of Melbourne, Victoria 3010, Australia.
⁹ CSL Limited at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
¹⁰ Department of Medicine, The University of Melbourne, Melbourne, Victoria 3010, Australia.
¹¹ Austin Health, Heidelberg, Victoria 3084, Australia.
¹² Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia. auldrich@qiuluzeuv.cn andreas.behren@qiuluzeuv.cn godfrey@qiuluzeuv.cn.
¹³ Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia. auldrich@qiuluzeuv.cn andreas.behren@qiuluzeuv.cn godfrey@qiuluzeuv.cn.

^# Contributed equally.

PMID: 31919129
DOI: 10.1126/science.aay5516

"VSports最新版本" Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

Marc Rigau et al. Science. 2020.

. 2020 Feb 7;367(6478):eaay5516.

doi: 10.1126/science.aay5516. Epub 2020 Jan 9.

Authors

Affiliations

¹ Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia.
² University of Bonn, Bonn, Germany.
³ Australian Research Council Centre of Excellence for Advanced Molecular Imaging at the University of Melbourne, Victoria 3010, Australia.
⁴ Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia.
⁵ School of Cancer Medicine, La Trobe University, Heidelberg, Victoria 3084, Australia.
⁶ Ludwig Institute for Cancer Research, Melbourne -Austin Branch, Victoria 3084, Australia.
⁷ Department of Biochemistry and Molecular Biology at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
⁸ Australian Research Council Centre of Excellence for Convergent Bio-Nano Science and Technology at the University of Melbourne, Victoria 3010, Australia.
⁹ CSL Limited at the Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria 3010, Australia.
¹⁰ Department of Medicine, The University of Melbourne, Melbourne, Victoria 3010, Australia.
¹¹ Austin Health, Heidelberg, Victoria 3084, Australia.
¹² Department of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Parkville, Victoria 3010, Australia. auldrich@qiuluzeuv.cn andreas.behren@qiuluzeuv.cn godfrey@qiuluzeuv.cn.
¹³ Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria 3084, Australia. auldrich@qiuluzeuv.cn andreas.behren@qiuluzeuv.cn godfrey@qiuluzeuv.cn.

^# Contributed equally.

PMID: 31919129
DOI: "V体育2025版" 10.1126/science.aay5516

Abstract

Gamma delta (γδ) T cells are essential to protective immunity. In humans, most γδ T cells express Vγ9Vδ2+ T cell receptors (TCRs) that respond to phosphoantigens (pAgs) produced by cellular pathogens and overexpressed by cancers VSports手机版. However, the molecular targets recognized by these γδTCRs are unknown. Here, we identify butyrophilin 2A1 (BTN2A1) as a key ligand that binds to the Vγ9+ TCR γ chain. BTN2A1 associates with another butyrophilin, BTN3A1, and these act together to initiate responses to pAg. Furthermore, binding of a second ligand, possibly BTN3A1, to a separate TCR domain incorporating Vδ2 is also required. This distinctive mode of Ag-dependent T cell activation advances our understanding of diseases involving pAg recognition and creates opportunities for the development of γδ T cell-based immunotherapies. .

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Antigen recognition by human γδ T cells: one step closer to knowing.
Eberl M. Eberl M. Immunol Cell Biol. 2020 May;98(5):351-354. doi: 10.1111/imcb.12334. Epub 2020 Apr 23. Immunol Cell Biol. 2020. PMID: 32329107 Free PMC article.

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Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

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"VSports最新版本" Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells

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