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. 2020 Jan 1;83(1):81-89.
doi: 10.1097/QAI.0000000000002229.

Intestinal Dysbiosis and Markers of Systemic Inflammation in Viscerally and Generally Obese Persons Living With HIV

Lasha Gogokhia  1   2 , Ying Taur  3 , Krishna Juluru  4   5 , Neda Yagan  4   6 , Yuan-Shan Zhu  7 , Eric Pamer  3   8 , Marshall J Glesby  9
Affiliations

"VSports在线直播" Intestinal Dysbiosis and Markers of Systemic Inflammation in Viscerally and Generally Obese Persons Living With HIV

Lasha Gogokhia et al. J Acquir Immune Defic Syndr. .

Abstract

Background: The intestinal microbiota contributes to the pathogenesis of obesity and metabolic disorders. People living with HIV (PLWH) have a higher risk for the development of visceral adiposity with accompanying worsened cardiovascular risk. VSports手机版.

Setting: Convenience sample from an HIV clinic and research unit. V体育安卓版.

Methods: To understand the relationship between adiposity and intestinal dysbiosis, we compared the gut microbiota and inflammatory markers in a cross-sectional study of viscerally obese, generally obese, and lean PLWH. Fecal intestinal microbiota was characterized by 16S ribosomal DNA sequencing V体育ios版. Abdominal CTs quantified subcutaneous adipose tissue and visceral adipose tissue (SAT; VAT). Serum high sensitivity C-reactive protein, adiponectin, leptin, IL-6, MCP-1, and sCD14 were assayed. .

Results: We studied 15, 9, and 11 participants with visceral obesity, general obesity, and lean body type, respectively. The generally obese group were all women and 2/3 African American, whereas the visceral obesity and lean groups were predominantly white and men who have sex with men. Markers of systemic inflammation and sCD14 were higher in general obesity compared with lean VSports最新版本. sCD14 was positively correlated with VAT, but not SAT. Bacterial diversity was significantly reduced in participants with visceral and general obesity and composition of intestinal microbiota was significantly different from lean body types. Bacterial alpha diversity was negatively correlated with VAT area, waist/hip ratio, and sCD14, but not with SAT area. .

Conclusions: In this exploratory study, obesity in general was associated with dysbiotic intestinal microbiota. The relationships of VAT to bacterial diversity and sCD14 suggest that dysbiosis in viscerally obese PLWH could be associated with heightened inflammatory state V体育平台登录. .

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Figures

Figure 1.
Figure 1.. Visceral adiposity is associated with higher levels of sCD14, but not with leptin.
Correlation of sCD14 (A, B) and leptin (C,D) with visceral and subcutaneous tissue area as determined by abdominal CT imaging.
Figure 2.
Figure 2.. Circulating adipokines and markers of systemic inflammation are altered in HIV+ participants with visceral and general obesity compared with lean body type.
Biomarkers of systemic inflammation were measured in serum and plasma of study participants by standard methods. HIV+ patients with either type of obesity had significantly elevated levels of hsCRP, IL-6, leptin and sCD14 compared with lean individuals. Additionally, hsCRP and leptin were significantly elevated in individuals with general compared with visceral obesity. p<0.05, **p<0.01, ***p<0.005, ****p<0.0001 as determined by Kruskal-Wallis test; pair-wise comparisons by Wilcoxon rank-sum test.
Figure 3.
Figure 3.. Intestinal Microbiota is altered in HIV+ participants with visceral and general obesity
Microbial community diversity analysis (Shannon Diversity Index) by body type (A). Measures of microbial beta-diversity based on an unweighted UniFrac distance (B). Relative abundance of a family classified fecal microbiota from patients with different body type (C).
Figure 4.
Figure 4.. Differentially represented bacteria between different body types identified by linear discriminant analysis coupled with effect size (LEfSe)
(A) Cladogram representation of differentially abundant bacteria among all three groups. Histogram of bacterial genera between (B) lean and viscerally obese individuals; (C) general vs viscerally obese individuals; (D) lean vs viscerally vs generally obese
Figure 5.
Figure 5.. Association of body fat distribution and sCD14 with bacterial diversity in people with HIV infection
Correlation between bacterial alpha-diversity measures with adiposity (A, B, C) and sCD14 (D) in HIV+ participants. Linear regression analysis and adjusted p-values are shown.
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V体育官网入口 - References

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