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. 2020 Feb;121(2):1998-2008.
doi: 10.1002/jcb.29434. Epub 2019 Nov 6.

Upregulation of SNHG14 suppresses cell proliferation and metastasis of colorectal cancer by targeting miR-92b-3p

Wei Zhang  1 , Wenfei Duan  2 , Zhifeng Mo  1 , Jianen Wang  1 , Wenbin Yang  1 , Wenrong Wu  1 , Xian Li  3 , Shuihua Lin  4 , Yuanfei Tan  1 , Wei Wei  1
Affiliations

Upregulation of SNHG14 suppresses cell proliferation and metastasis of colorectal cancer by targeting miR-92b-3p

Wei Zhang (V体育官网入口) et al. J Cell Biochem. 2020 Feb.

V体育平台登录 - Abstract

Ample evidence have demonstrated that long noncoding RNAs small nucleolus RNA host gene 14 (SNHG14) serves as a master regulator in various cancers. However, the exact mechanism of SNHG14 in colorectal cancer (CRC) remains unknown. In the present study, we concentrate on the potential function of SNHG14 in the pathogenesis of CRC. From the quantitative reverse transcription-polymerase chain reaction results, SNHG14 was found to be downregulated in CRC tissues compared with the normal mucous samples, and its low expression was significantly correlated with poor clinical outcomes VSports手机版. Overexpression of SNHG14 inhibited cell growth, induced cell apoptosis, suppressed migration and invasion by inhibiting epithelial-mesenchymal transition process. Furthermore, mechanistic studies revealed that miR-92b-3p could rescue the CRC progress induced by SNHG14. Consequently, SNHG14 exhibited low expression in CRC tissues and involved in CRC progression and metastasis by competing for miR-92b-3p, and SNHG14 could be used as a valuable biomarker and therapeutic target for CRC. .

Keywords: SNHG14; colorectal cancer; long noncoding RNA; metastasis; miRNA-92b-3p. V体育安卓版.

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References

REFERENCES

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