Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in VSports app下载. gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. V体育官网.

. 2019 Dec 1:428:152304.
doi: 10.1016/j.tox.2019.152304. Epub 2019 Oct 3.

Zearalenone induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells

Xue Wang  1 , Liping Jiang  2 , Limin Shi  3 , Kun Yao  4 , Xiance Sun  5 , Guang Yang  3 , Lijie Jiang  6 , Cong Zhang  3 , Ningning Wang  3 , Hongying Zhang  7 , Yan Wang  8 , Xiaofang Liu  9
Affiliations

Zearalenone induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells (V体育2025版)

Xue Wang et al. Toxicology. .

"VSports手机版" Abstract

Zearalenone (ZEA), one of the mycotoxins widely found in food and feed, can stimulate an inflammatory reaction. In the present study, we demonstrated that ZEA induced the activation of NLRP3 inflammasome even pyroptotic cell death in rat Insulinoma Cell Line (INS-1). Meanwhile, according to the results of western blot and TEM, the level of autophagy was elevated by ZEA, which protected against the activation of NLRP3 inflammasome and inflammatory response caused by ZEA. Furthermore, we indicated that ZEA-induced NF-κB p65 activation contributed to the activation of the NLRP3 inflammasome, inflammatory response, and pyroptosis in INS-1 cells, which were indicated by western blot and immunofluorescence, and the activation of NF-κB p65 induced by ZEA was autophagy-dependent VSports手机版. This study demonstrates that ZEA induces NLRP3-dependent pyroptosis via activation of NF-κB modulated by autophagy in INS-1 cells. .

Keywords: Autophagy; NF-κB p65; NLRP3 inflammasome; Pyroptosis; Zearalenone. V体育安卓版.

PubMed Disclaimer

Publication types

Substances

VSports最新版本 - LinkOut - more resources