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Review
. 2019 Sep 13;18(1):136.
doi: 10.1186/s12943-019-1069-0.

VSports app下载 - Biogenesis, functions and clinical significance of circRNAs in gastric cancer

Chan Shan  1 , Yinfeng Zhang  2 , Xiaodan Hao  2 , Jinning Gao  2 , Xinzhe Chen  2 , Kun Wang  3
Affiliations
Review

Biogenesis, functions and clinical significance of circRNAs in gastric cancer

Chan Shan et al. Mol Cancer. .

Abstract (V体育安卓版)

Gastric cancer (GC) is one of the most common malignant tumours in the world and has high morbidity and mortality. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently linked circular structures. In recent years, plentiful circRNAs have been discovered that participate in many biological processes, including the initiation and development of tumours. Increasing evidences suggest important biological functions of circRNAs, implying that circRNAs may serve as vital new biomarkers and targets for disease diagnosis and prognosis. Among these, circRNAs are tend to aberrantly expressed and are regarded as potential biomarkers in the carcinogenesis and progression of GC VSports手机版. This review systematically summarised the biogenesis, biological properties and functions of circRNAs, with a focus on their relationship with GC, as well as their probable clinical implications on GC. As our cognition of the relation between circRNAs and GC deepens, more molecular mechanisms of GC progression will be discovered, and new therapeutic strategies will be used for the prevention and treatment of GC. .

Keywords: Biomarker; Circular RNA; Gastric cancer; Therapeutic target. V体育安卓版.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Biogenesis of circRNAs. a liner mRNA: a single-stranded ribonucleic acids carrying genetic information; (b) lariat-driven circularization: this model requires the covalently binding between the splicing donor and splicing acceptor, thus forming an exon-containing lariat; (c) intron-pairing-driven circularization: intronic complementary base-pairs bring the adjacent two exons close together. The exons and introns are then cut away by spliceosome to form cirRNAs; (d) intron cyclization: intron is cleaved from the pre-mRNA to form a ciRNA
Fig. 2
Fig. 2
Functions of circRNAs. a circRNAs competitively bind miRNAs, so as to serve as intracellular competitive endogenous RNA, suppressing the effects of miRNAs on target genes. b circRNAs serve as protein baits or antagonists, thus arrestting the function of proteins, thereby affecting the related progresses. c circRNAs can translate to proteins through a cap-independent manner. d cirRNAs complete with the linear RNAs to get a balance. Some splicing factors may participate in this process, increasing the formation of circRNAs while reducing the linear splicing. e circRNAs interact with RNA polymerase II or transcription related factors, regulating the transcription and expression of parental genes
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