Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil VSports app下载. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure V体育官网. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. .

Case Reports
. 2019 Aug 3:16:100528.
doi: 10.1016/j.ajoc.2019.100528. eCollection 2019 Dec.

"VSports注册入口" Orbital metastasis from a gastrointestinal stromal tumor: A case report

Yan Yu  1 , Xiaoqian Ji  1 , Wei Li  1 , Changfan Wu  1
Affiliations
Case Reports

Orbital metastasis from a gastrointestinal stromal tumor: A case report

"V体育平台登录" Yan Yu et al. Am J Ophthalmol Case Rep. .

"V体育安卓版" Abstract

Background: Gastrointestinal stromal tumor (GIST) is the most common primary mesenchymal tumor. The most common metastasis sites are the liver and the surface of the peritoneum VSports手机版. In this study, we present a case of orbital GIST metastasis. .

Case presentation: A 43-year-old woman who had a history of small intestinal stromal tumor 4 years ago suffered GIST metastasis to the left orbit. MRI confirmed the presence of a lacrimal gland lesion with isointense on T1 and hyperintense on T2 weighted images. Histopathology analysis of the tumor showed predominantly spindle or oval cells with nuclear pleomorphism and increased mitoses. The tumor also stained positive for c-KIT (CD117) upon immunochemistry, confirming the diagnosis V体育安卓版. .

Conclusions: GISTs typically occur as sporadic solitary tumors, and their common metastasis sites are the liver and the surface of the peritoneum. Orbital involvement is extremely rare. The orbital GIST metastatic tumor has special imaging properties, as evidenced by histopathology, immunochemistry, and magnetic resonance imaging (MRI). V体育ios版.

Keywords: CD117; Gastrointestinal stromal tumors (GISTs); Metastasis; Orbit VSports最新版本. .

PubMed Disclaimer

"VSports最新版本" Figures

Fig. 1
Fig. 1
At high power (400 × ), immunohistochemical staining was positive for CD117 (400 × ) in the orbital metastasis (Fig.1A). At a high power (400 × ), hematoxylin and eosin staining of the tumor revealed a cellular neoplasm composed of sheets of epithelioid and spindled cells, with round or oval nuclei. The nuclei of the tumor cells were unusual upon digital microscopy. Here, abnormal mitoses are indicated with arrows in the photograph (Fig.1B). At high power (400 × ), immunohistochemical staining was partly positive for CD34 in the orbital metastasis (Fig. 1C). At high power (400 × ), immunohistochemical staining was positive for DOG-1, KI-67 and S-100 in the orbital metastasis (Fig. 1D, E and F).
Fig. 2
Fig. 2
MRI confirmed the presence of a lacrimal gland lesion with isointense to eye muscles on T1 and hyperintense on T2 weighted images (Fig. 2B and .C). Coronal T1-weighted strengthened scanning images after gadolinium injection showed enhancement (Fig. 2A).
Fig. 3
Fig. 3
Optical coherence tomography (OCT) vertical scanning showed optic disc and retinal edema.
See this image and copyright information in PMC

References

    1. Stamatakos M., Douzinas E., Stefanaki C. Gastrointestinal stromal tumor. World J Surg Oncol. 2009;7:61. - PMC - PubMed
    1. Akiyama K., Numaga J., Kagaya F. Case of optic nerve involvement in metastasis of a gastrointestinal stromal tumor. Jpn J Ophthalmol. 2004;48(2):166–168. - PubMed
    1. Li L.F., Tse Y.H., Ho S.L., Yan K.W., Lui W.M. Duodenal GIST metastasized to skull and orbit managed by surgery: a case report. Asian J Surg. 2011;34(4):181–184. - PubMed
    1. Woo D., Leong J., Waring D., Sharma A., Martin P. Orbital gastrointestinal stromal tumor metastasis. Orbit. 2012;31(2):129–131. - PubMed (V体育2025版)
    1. Downs-Kelly E., Rubin B.P. Gastrointestinal stromal tumors: molecular mechanisms and targeted therapies. Pathol Res Int. 2011;2011:708596. - PMC - PubMed

LinkOut - more resources