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Review
. 2019 May 16:14:1045-1051.
doi: 10.2147/COPD.S155306. eCollection 2019.

Targeting IL-5 in COPD

Dharani K Narendra  1 , Nicola A Hanania  1
Affiliations
Review

Targeting IL-5 in COPD

Dharani K Narendra et al. Int J Chron Obstruct Pulmon Dis. .

Abstract

Many patients with chronic obstructive pulmonary disease (COPD) continue to experience exacerbations despite receiving standard-of-care treatments. Novel approaches to COPD treatment focus on understanding and targeting molecular mechanisms of airway inflammation, airway obstruction, remodeling and lung destruction VSports手机版. Several identified phenotypes and endotypes of COPD will pave the future path for a more personalized approach to therapy. Although well known to be associated with neutrophilic inflammation, COPD may also be driven by eosinophilic inflammation both at stable states and during exacerbation. Targeting eosinophilic inflammation has been successful in managing severe eosinophilic asthma and may hold promise in certain phenotypes of COPD. The most promising biologic treatments at an advanced stage of development are agents blocking interleukin (IL)-5 or its receptor. This review examines our current understanding of the eosinophilic inflammation in COPD and the rationale for IL-5 targeting agents. .

Keywords: COPD; IL-5; airway inflammation; benralizumab; eosinophils; mepolizumab V体育安卓版. .

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Conflict of interest statement

DKN has no conflicts of interest to disclose in this work V体育ios版. NAH received honoraria for serving as consultant or on advisory boards for GSK, Astra Zeneca, Sanofi/Regeneron, Novartis, Boehringer Ingelheim, Sunovion, Mylan and Gossamer Bio. His institutions have received research grant support on his behalf from Astra Zeneca, GSK, Boehringer Ingelheim.

Figures (VSports手机版)

Figure 1
Figure 1
T2 inflammatory pathway and the target site for anti-IL-5 agents. Abbreviations: CRTh2, chemoattractant receptor homolog from Th2 cells; ILC2, innate lymphoid cells; TSLP, thymic stromal lymphopoietin; IL, Interleukin.
See this image and copyright information in PMC

References

    1. Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report: GOLD executive summary. Arch Bronconeumol. 2017;53(3):128–149. doi:10.1016/j.arbres.2017.02.001 - DOI - PubMed
    1. https://www.who.int/news-room/fact-sheets/detail/chronic-obstructive-pul...); 2017. Accessed February25, 2019.
    1. Croft JB, Wheaton AG, Liu Y, et al. Urban-rural county and state differences in chronic obstructive pulmonary disease – United States, 2015. Morb Mortal Wkly Rep. 2018;67(7):205–211. doi:10.15585/mmwr.mm6707a1 - "V体育安卓版" DOI - PMC - PubMed
    1. Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax. 2002;57(10):847–852. - PMC - PubMed
    1. Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010;363(12):1128–1138. doi:10.1056/NEJMoa0909883 - DOI - PubMed

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