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. 2019 Jul 10:454:53-65.
doi: 10.1016/j.canlet.2019.04.014. Epub 2019 Apr 11.

"VSports" Pseudophosphatase STYX promotes tumor growth and metastasis by inhibiting FBXW7 function in colorectal cancer

Diao He  1 , Zida Ma  1 , Chao Fang  1 , Jingjing Ding  2 , Wenming Yang  2 , Peng Chen  2 , Libin Huang  1 , Cun Wang  2 , Yongyang Yu  2 , Lie Yang  3 , Yuan Li  4 , Zongguang Zhou  5
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Pseudophosphatase STYX promotes tumor growth and metastasis by inhibiting FBXW7 function in colorectal cancer

Diao He et al. Cancer Lett. .

Abstract

Serine/threonine/tyrosine interacting protein (STYX), a member of protein tyrosine phosphatases, has recently been reported as a potential oncogene VSports手机版. However, the role of STYX in colorectal cancer (CRC) remains unknown. In this study, we found that STYX was highly expressed in CRC tissues and closely correlated with tumor development and survival of CRC patients. In vitro studies showed that overexpression of STYX promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) and inhibited apoptosis in CRC cells, while STYX knockdown had the opposite effects. Consistently, in vivo experiments showed that overexpression of STYX promoted tumor growth and lung metastasis. Mechanically, STYX bound to the F-box and WD repeat domain-containing7 (FBXW7) protein and inhibited its function. Co-regulation of STYX and FBXW7 expression reversed the biological changes mediated by regulation of STYX expression alone in CRC cells. Additionally, FBXW7 expression was negatively associated with STYX expression in CRC tissues, and low STYX levels accompanying high FBXW7 levels predicted favorable prognosis of CRC patients. In conclusion, our results suggest that STYX plays an oncogenic role by inhibiting FBXW7 and represents a potential therapeutic target and prognostic biomarker in CRC. .

Keywords: EMT; Oncogene; Prognostic biomarker; Protein tyrosine phosphatases V体育安卓版. .

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