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. 2019 Feb 4:2019:3140204.
doi: 10.1155/2019/3140204. eCollection 2019.

Serum Leucine-Rich α 2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis (VSports最新版本)

Masaki Shimizu  1 , Natsumi Inoue  1 , Mao Mizuta  1 , Yasuo Nakagishi  2 , Akihiro Yachie  1
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Serum Leucine-Rich α 2-Glycoprotein as a Biomarker for Monitoring Disease Activity in Patients with Systemic Juvenile Idiopathic Arthritis

Masaki Shimizu et al. J Immunol Res. .

VSports - Abstract

To investigate whether serum leucine-rich α2-glycoprotein (LRG) levels are useful as a marker of disease activity in systemic juvenile idiopathic arthritis (s-JIA), we determined serum LRG levels in fifty-nine s-JIA patients, 15 with other subtypes of JIA, 7 with Kawasaki disease (KD), 7 with influenza A infection (flu), 7 with enterohemorrhagic Escherichia coli (EHEC) infection, and 20 healthy controls (HC). Results were compared with the clinical features of s-JIA and serum cytokine levels including interleukin- (IL-) 6, IL-18, and soluble tumor necrosis factor receptors I and II. Serum LRG levels in active s-JIA were higher compared to those in other subtypes of JIA, EHEC, flu patients, and HC VSports手机版. Serum LRG levels were normalized in the inactive s-JIA phase after treatment. Serum LRG levels were positively correlated with serum C-reactive protein and ferritin levels. Serum LRG levels reflected s-JIA disease activity and thus may be useful for monitoring s-JIA disease activity. .

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Figures

Figure 1
Figure 1
Serum levels of LRG in patients with s-JIA and other various diseases. Bars represent median values. Statistically significant differences between each patient group are shown as ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.01, and ∗∗∗∗p < 0.0001. LRG: leucine-rich α2-glycoprotein; s-JIA: systemic juvenile idiopathic arthritis; RF+ polyJIA: rheumatoid factor-positive polyarticular JIA; oligoJIA: oligoarticular JIA; ERA: enthesitis-related arthritis; KS: Kawasaki disease; flu: influenza A infection; EHEC: enterohemorrhagic Escherichia coli infection; HC: healthy controls.
Figure 2
Figure 2
Changes in serum LRG in patients with s-JIA. (a) Serum LRG levels in each s-JIA phase are shown. (b) Changes in serum LRG level are shown. Statistically significant differences between each patient group are shown as ∗∗p < 0.01, ∗∗∗p < 0.01, and ∗∗∗∗p < 0.0001. LRG: leucine-rich α2-glycoprotein.
Figure 3
Figure 3
Correlations between serum LRG levels and other measures of disease activity. Serum LRG levels were compared with other serum biomarker levels in s-JIA patients. (a) CRP, (b) ferritin, (c) AST, (d) LDH, (e) IL-6, (f) IL-18, (g) sTNFRI, and (h) sTNFRII. Black boxes indicate the values in s-JIA patients. LRG: leucine-rich α2-glycoprotein; CRP: C-reactive protein; AST: aspartate aminotransferase; LDH: lactate dehydrogenase; IL: interleukin; sTNFR: soluble tumor necrosis factor receptor.
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