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. 2019 Jan 14;35(1):64-80.e7.
doi: 10.1016/j.ccell.2018.11.016. Epub 2019 Jan 3.

Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling (V体育官网入口)

Minhong Shen  1 , Yi-Zhou Jiang  2 , Yong Wei  1 , Brian Ell  1 , Xinlei Sheng  1 , Mark Esposito  1 , Jooeun Kang  1 , Xiang Hang  1 , Hanqiu Zheng  1 , Michelle Rowicki  1 , Lanjing Zhang  3 , Weichung J Shih  4 , Toni Celià-Terrassa  1 , Yirong Liu  2 , IIeana Cristea  1 , Zhi-Ming Shao  2 , Yibin Kang  5
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Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

"VSports手机版" Minhong Shen et al. Cancer Cell. .
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"VSports注册入口" Abstract

Triple-negative breast cancer (TNBC) patients have the worst prognosis and distant metastasis-free survival among all major subtypes of breast cancer VSports手机版. The poor clinical outlook is further exacerbated by a lack of effective targeted therapies for TNBC. Here we show that ectopic expression and therapeutic delivery of the secreted protein Tubulointerstitial nephritis antigen-like 1 (Tinagl1) suppresses TNBC progression and metastasis through direct binding to integrin α5β1, αvβ1, and epidermal growth factor receptor (EGFR), and subsequent simultaneous inhibition of focal adhesion kinase (FAK) and EGFR signaling pathways. Moreover, Tinagl1 protein level is associated with good prognosis and reversely correlates with FAK and EGFR activation status in TNBC. Our results suggest Tinagl1 as a candidate therapeutic agent for TNBC by dual inhibition of integrin/FAK and EGFR signaling pathways. .

Keywords: EGFR; FAK; Tinagl1; extracellular matrix; integrin; metastasis; triple-negative breast cancer; tumor-stromal interaction V体育安卓版. .

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