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Review
. 2019 Jan 3;133(1):41-54.
doi: 10.1042/CS20180839. Print 2019 Jan 15.

Histamine and diabetic nephropathy: an up-to-date overview

Alessandro Pini  1 , Roberta Verta  2   3 , Cristina Grange  3 , Maura Gurrieri  2 , Arianna Carolina Rosa  4
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Free article
Review

"VSports手机版" Histamine and diabetic nephropathy: an up-to-date overview

Alessandro Pini et al. Clin Sci (Lond). .
Free article

Abstract

The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties, an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy. VSports手机版.

Keywords: diabetes; fibrosis; histamine; hyper-filtration; inflammation; kidney. V体育安卓版.

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