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. 2018 Dec 5;13(12):e0208017.
doi: 10.1371/journal.pone.0208017. eCollection 2018.

High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection

Paula S Mantula  1 , Tuula K Outinen  1 , Pia Jaatinen  2   3 , Mari Hämäläinen  4 , Heini Huhtala  5 , Ilkka H Pörsti  1   2 , Antti Vaheri  6 , Jukka T Mustonen  1   2 , Satu M Mäkelä  1   2
Affiliations

High plasma resistin associates with severe acute kidney injury in Puumala hantavirus infection

Paula S Mantula et al. PLoS One. .

Abstract

Background: Puumala hantavirus (PUUV) infected patients typically suffer from acute kidney injury (AKI) VSports手机版. Adipokines have inflammation modulating functions in acute diseases including AKI. We examined plasma levels of three adipokines (resistin, leptin, and adiponectin) in acute PUUV infection and their associations with disease severity. .

Methods: This study included 79 patients hospitalized due to acute PUUV infection. Plasma resistin, leptin, adiponectin, as well as IL-6 and CRP, were measured at the acute phase, recovery phase and one year after hospitalization V体育安卓版. .

Results: Plasma resistin levels were significantly higher in the acute phase compared to the recovery phase and one year after (median resistin 28 pg/mL (11-107) vs. 17 pg/mL (7-36) vs V体育ios版. 14 pg/mL (7-31), p<0. 001). Maximum resistin concentration correlated with maximum plasma creatinine levels (r = 0. 63; p<0. 001). The higher the amount of albuminuria in the urine dipstick test (0-1+, 2+ or 3+) at admission, the higher the median of maximum resistin (24. 7 pg/mL, 25. 4 pg/mL and 39. 6 pg/mL, respectively, p = 0. 002). High resistin was also an independent risk factor for severe AKI (creatinine ≥353. 6μmol/L) (OR 1. 08, 95% CI 1. 02-1. 14). Neither plasma leptin nor adiponectin level had any correlation with creatinine concentration or the amount of albuminuria. .

Conclusions: Plasma resistin independently associates with the severity of AKI in acute PUUV infection VSports最新版本. The association of resistin with the amount of albuminuria suggests that the level of plasma resistin is not only influenced by renal clearance but could have some role in the pathogenesis of AKI during PUUV infection. .

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Conflict of interest statement

The authors have declared that no competing interests exist.

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Fig 1
Fig 1
Plasma resistin (A), leptin (B), and adiponectin (C) levels during acute Puumala hantavirus (PUUV) infection, in the recovery phase, and one year after the hospitalization. Median (thick line inside box), 25th-75th percentiles (box), range (whiskers), and outliers (○).
Fig 2
Fig 2. Receiver operating characteristic (ROC) curves for plasma resistin and different plasma inflammatory markers (maximum C-reactive protein, maximum interleukin-6, and maximum leukocyte count) in predicting severe acute kidney injury (plasma creatinine ≥353.6 μmol/L) during acute Puumala hantavirus infection.
See this image and copyright information in PMC

References

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