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. 2018 Nov 5;5(11):ofy288.
doi: 10.1093/ofid/ofy288. eCollection 2018 Nov.

I-FABP Is Higher in People With Chronic HIV Than Elite Controllers, Related to Sugar and Fatty Acid Intake and Inversely Related to Body Fat in People With HIV

Lediya T Cheru  1 , Elli A Park  1 , Charles F Saylor  1 , Tricia H Burdo  2 , Kathleen V Fitch  1 , Sara Looby  1 , Jeffrey Weiner  1 , Jake A Robinson  2 , Jane Hubbard  3 , Martin Torriani  4 , Janet Lo  1
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"VSports手机版" I-FABP Is Higher in People With Chronic HIV Than Elite Controllers, Related to Sugar and Fatty Acid Intake and Inversely Related to Body Fat in People With HIV

Lediya T Cheru et al. Open Forum Infect Dis. .

V体育ios版 - Abstract

Background: Intestinal fatty acid binding protein (I-FABP) has been shown to be a marker of intestinal damage among people living with HIV VSports手机版. We hypothesized that I-FABP would be increased in chronically HIV-infected patents more than elite controllers and would relate to specific nutrient intake and body composition. .

Methods: In an observational study, serum I-FABP was measured by enzyme-linked immunosorbent assay. Anthropometric measurements, dual-energy x-ray absorptiometry, and single-slice abdominal computed tomography were obtained to assess body composition, as well as visceral and subcutaneous adipose tissue areas (VAT and SAT). Dietary intake was assessed using 4-day food records V体育安卓版. .

Results: One hundred forty-nine people with chronic HIV (65% male, 47 ± 7 years of age, 54. 7% white, and 14 ± 6 years of known HIV), 10 elite controllers (60% male, 53 ± 8 years, 60% white, and 20 ± 7 years of known HIV), and 69 HIV-negative controls (59 V体育ios版. 4% male, 46 ± 7 years, and 52. 2% white) were included in the analysis. I-FABP was significantly higher in HIV progressors relative to HIV-negative controls and elite controllers. In the chronic HIV group, I-FABP was positively associated with dietary intake of added sugar and with saturated fatty acids. I-FABP was inversely associated with body mass index, VAT, and SAT. I-FABP also correlated with MCP-1, CXCL10, sCD163, and lipopolysaccharide (LPS) among all participants. .

Conclusions: I-FABP was increased among chronically HIV-infected patients to a greater degree than in elite controllers and was related to nutrient intake and body composition in HIV progressors. Future studies to investigate the role of intestinal damage on nutrient absorption are needed to elucidate the mechanisms of these relationships VSports最新版本. .

Trial registration identifier: NCT00455793 V体育平台登录. .

Keywords: HIV; body composition; intestinal fatty acid binding protein; microbial translocation; nutrition VSports注册入口. .

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"VSports最新版本" Figures

Figure 1.
Figure 1.
Blue circles denote HIV-negative controls, purple squares denote elite controllers, and red triangles are chronic HIV. Abbreviation: I-FABP, intestinal fatty acid protein.
Figure 2.
Figure 2.
Blue circles denote body mass index, red circles denote visceral adipose tissue, and green circles denote subcutaneous adipose tissue. Abbreviations: BMI, body mass index; I-FABP, intestinal fatty acid binding protein; SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue.
Figure 3.
Figure 3.
Proposed mechanisms of intestinal damage, intestinal fatty acid binding protein release, and effects on body composition. Abbreviations: BMI, body mass index; I-FABP, intestinal fatty acid binding protein.
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