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Review
. 2018 Nov 17;17(1):158.
doi: 10.1186/s12943-018-0900-3.

V体育安卓版 - Role of the NLRP3 inflammasome in cancer

Maryam Moossavi  1   2 , Negin Parsamanesh  1   2 , Afsane Bahrami  2 , Stephen L Atkin  3 , Amirhossein Sahebkar  4   5   6
Affiliations
Review

Role of the NLRP3 inflammasome in cancer

Maryam Moossavi et al. Mol Cancer. .

Abstract

Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1 VSports手机版. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy. .

Keywords: Apoptosis-associated speck-like protein; Caspase-1; Interleukin-1β; Nod-like receptor protein 3 V体育安卓版. .

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Conflict of interest statement

Ethics approval and consent to participate

No ethics approval was required for this review that did not involve patients or patient data.

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All authors consent to publication.

Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
Schematic diagram of NLR gene family
Fig. 2
Fig. 2
Activation and signaling of NLRP3 inflammasome. BTK(Bruton’s tyrosine kinase), CaMKII (Calcium/calmodulin-dependent protein kinase II), DAMPs(damage associated molecular patterns), DHX33(DEAH-box helicase 33), ER(endoplasmic reticulum), IL(Interleukin), JAK1(Janus family of protein tyrosine kinases), LPS(Lipopolysaccharide), MCU(mitochondrial Ca 2+ uniporter), Nuclear factor-κB (NF-κB), NLRP3(NLR family, pyrin domain containing 3), NOD(nucleotide-binding and oligomerization), PAMPs(pathogen associated molecular patterns), PKR(protein kinase R), SHP(small heterodimer partner (SHP), TNF (tumor necrosis factor), Trim33(Tripartite motif-containing protein 33), VDAC1/2(voltage-dependent anion-selective channel 1/2)
See this image and copyright information in PMC

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