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. 2018 Nov 1;18(1):292.
doi: 10.1186/s12906-018-2356-9.

Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis

Guohua Yu  1 , Wubin Wang  1 , Xu Wang  1 , Meng Xu  1 , Lili Zhang  1 , Lei Ding  1 , Rui Guo  1 , Yuanyuan Shi  2   3
Affiliations

"VSports最新版本" Network pharmacology-based strategy to investigate pharmacological mechanisms of Zuojinwan for treatment of gastritis

Guohua Yu et al. BMC Complement Altern Med. .

Abstract

Background: Zuojinwan (ZJW), a classic herbal formula, has been extensively used to treat gastric symptoms in clinical practice in China for centuries. However, the pharmacological mechanisms of ZJW still remain vague to date. VSports手机版.

Methods: In the present work, a network pharmacology-based strategy was proposed to elucidate its underlying multi-component, multi-target, and multi-pathway mode of action against gastritis. First we collected putative targets of ZJW based on TCMSP and STITCH databases, and a network containing the interactions between the putative targets of ZJW and known therapeutic targets of gastritis was built. Then four topological parameters, "degree", "betweenness", "closeness", and "coreness" were calculated to identify the major targets in the network V体育安卓版. Furthermore, the major hubs were imported to the Metacore database to perform a pathway enrichment analysis. .

Results: A total of 118 nodes including 59 putative targets of ZJW were picked out as major hubs in terms of their topological importance. The results of pathway enrichment analysis indicated that putative targets of ZJW mostly participated in various pathways associated with anti-inflammation response, growth and development promotion and G-protein-coupled receptor signaling. More importantly, five putative targets of ZJW (EGFR, IL-6, IL-1β, TNF-α and MCP-1) and two known therapeutic targets of gastritis (CCKBR and IL-12β) and a link target NF-κB were recognized as active factors involved in the main biological functions of treatment, implying the underlying mechanisms of ZJW acting on gastritis V体育ios版. .

Conclusion: ZJW could alleviate gastritis through the molecular mechanisms predicted by network pharmacology, and this research demonstrates that the network pharmacology approach can be an effective tool to reveal the mechanisms of traditional Chinese medicine (TCM) from a holistic perspective VSports最新版本. .

Keywords: Gastritis; Network pharmacology; Zuojinwan. V体育平台登录.

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Conflict of interest statement

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Competing interests

The authors declare that they have no competing interests.

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Figures

Fig. 1
Fig. 1
The flowchart of network pharmacology-based strategy for deciphering the mechanisms of ZJW acting on gastritis. Abbreviations: ZJW, Zuojinwan; TCMSP, Traditional Chinese Medicine Systems Pharmacology; CASC, Chinese Academy of Sciences Chemistry; OMIM, Online Mendelian Inheritance in Man; PPI, protein–protein interaction
Fig. 2
Fig. 2
Main pathways enriched by major hubs from Metacore database. The top 10 pathways measured by counts were selected to demonstrate the crucial biological actions of major hubs. The abscissa stands for target counts in each pathway; and the ordinate stands for main pathways
Fig. 3
Fig. 3
The interaction network between major hubs and main pathways. Round red nodes stand for putative targets of ingredients contained in ZJW; round orange nodes stand for known therapeutic targets for gastritis; round green nodes stand for the main link targets between red nodes and orange nodes; blue diamonds stand for main pathways based on enrichment analysis of major hubs
Fig. 4
Fig. 4
Null model network. a The null model network composed of the same nodes and the number of edges from ZJW network but randomized links based on Erdös-Renyí model. b The core structure of null model network after calculation of four topological properties
Fig. 5
Fig. 5
Illustration of crucial biological progress caused by putative targets and known therapeutic targets for gastritis. Abbreviations: EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; CCKBR, cholecystokinin-B receptors; PI3K, phosphoinositide 3-kinase; AKT, protein kinase B; Ca2+, Calcium ion; AC, adenylyl cyclase; cAMP, cyclic adenosine monophosphate; NF-κB, nuclear factor kappa B; IL-1β, interleukin 1 beta; IL-6, interleukin 6; MCP-1, monocyte chemotactic protein-1; TNF-α, tumor necrosis factor alpha; IL-12β, interleukin 12 beta; ZJW, Zuojinwan
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