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Review
. 2018 Dec;51(6):e12506.
doi: 10.1111/cpr.12506. Epub 2018 Aug 9.

CASC2: An emerging tumour-suppressing long noncoding RNA in human cancers and melanoma (VSports注册入口)

Xin Yu  1 , Heyi Zheng  1 , Gary Tse  2 , Lin Zhang  3 , William Ka Kei Wu  3   4
Affiliations
Review

CASC2: An emerging tumour-suppressing long noncoding RNA in human cancers and melanoma

Xin Yu et al. Cell Prolif. 2018 Dec.

Abstract

Deregulation of long noncoding RNAs (lncRNAs) has been implicated in tumourigenesis. Cancer Susceptibility Candidate 2 (CASC2) is a lncRNA downregulated in multiple cancer types, including endometrial, lung, gastric and colorectal cancers. CASC2 functions as a tumour-suppressive lncRNA though multiple mechanisms, such as sequestration of oncogenic microRNAs and repression of Wnt/β-catenin signalling. Pertinent to clinical practice, the use of CASC2 as a prognostic marker has been demonstrated in sporadic studies VSports手机版. These findings suggested that CASC2 might play an important role in human cancers and melanoma. More efforts are warranted to examine the function role of CASC2 in other cancer types. Further validation is also needed to promote its development to be a clinically utilizable prognostic biomarker. .

Keywords: lncRNA; melanoma; prognostic marker; tumour suppressor V体育安卓版. .

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Conflict of interest statement

The authors declare no competing financial interests.

VSports app下载 - Figures

Figure 1
Figure 1
Upstream mechanisms underlying CASC2 downregulation and downstream effector pathways of CASC2 in human cancers. Genetic mechanisms (ie, point mutations and copy number loss) and aberrant upregulation of miR‐21 contribute to loss‐of‐function or downregulation of CASC2 in human cancers. CASC2 exerts its tumour‐suppressive effects through chelation of oncogenic microRNAs (eg, miR‐18a, miR‐21 and miR‐181a) and inhibition of oncogenic pathways (eg, Wnt/β‐catenin, ERK/MAPK and JNK)
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