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. 2018 Jul;67(7):1113-1121.
doi: 10.1007/s00262-018-2169-1. Epub 2018 May 8.

VISTA expression on tumor-infiltrating inflammatory cells in primary cutaneous melanoma correlates with poor disease-specific survival

Lawrence F Kuklinski  1   2 , Shaofeng Yan  3 , Zhongze Li  4 , Jan L Fisher  5 , Chao Cheng  6 , Randolph J Noelle  7 , Christina V Angeles  8 , Mary Jo Turk  7 , Marc S Ernstoff  9
Affiliations

VISTA expression on tumor-infiltrating inflammatory cells in primary cutaneous melanoma correlates with poor disease-specific survival

Lawrence F Kuklinski et al. Cancer Immunol Immunother. 2018 Jul.

Abstract

Adaptive immune responses contribute to the pathogenesis of melanoma by facilitating immune evasion. V-domain Ig suppressor of T-cell activation (VISTA) is a potent negative regulator of T-cell function and is expressed at high levels on monocytes, granulocytes, and macrophages, and at lower densities on T-cell populations within the tumor microenvironment. In this study, 85 primary melanoma specimens were selected from pathology tissue archives and immunohistochemically stained for CD3, PD-1, PD-L1, and VISTA. Pearson's correlation coefficients identified associations in expression between VISTA and myeloid infiltrate (r = 0. 28, p = 0. 009) and the density of PD-1+ inflammatory cells (r = 0. 31, p = 0. 005). The presence of VISTA was associated with a significantly worse disease-specific survival in univariate analysis (hazard ratio = 3. 57, p = 0. 005) and multivariate analysis (hazard ratio = 3. 02, p = 0. 02). Our findings show that VISTA expression is an independent negative prognostic factor in primary cutaneous melanoma and suggests its potential as an adjuvant immunotherapeutic intervention in the future. VSports手机版.

Keywords: Checkpoint inhibitor; Melanoma; Survival; Tumor microenvironment; Tumor-infiltrating lymphocytes; VISTA. V体育安卓版.

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Conflict of interest statement

Randolph J. Noelle is the co-founder of ImmuNext. All other authors declare no conflicts of interest V体育ios版.

Figures

Fig. 1
Fig. 1
Representative immunohistochemical staining patterns. a CD3 expression in TIIC. b VISTA expression in tumor-infiltrating neutrophils and rare mononuclear cells. c PD-L1 expression in melanoma cells. d PD-L1 expression in TIIC. e PD-1 expression in TIIC. f Negative control (original magnification ×400). Arrows indicate positively stained cells
Fig. 2
Fig. 2
Kaplan–Meier disease specific survival curve by VISTA expression in tumor-infiltrating inflammatory cells
See this image and copyright information in PMC

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