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Review
. 2018 Sep;39(9):677-696.
doi: 10.1016/j.it.2018.04.002. Epub 2018 Apr 30.

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

Joannie M Allaire  1 , Shauna M Crowley  1 , Hong T Law  2 , Sun-Young Chang  3 , Hyun-Jeong Ko  4 , Bruce A Vallance  5
Affiliations
Review

The Intestinal Epithelium: Central Coordinator of Mucosal Immunity

"V体育官网入口" Joannie M Allaire et al. Trends Immunol. 2018 Sep.

Erratum in

Abstract (VSports在线直播)

The gastrointestinal (GI) tract represents a unique challenge to the mammalian immune system. It must tolerate the presence of the luminal microbiota and thus not respond to their products, but still protect the intestinal mucosa from potentially harmful dietary antigens and invading pathogens. The intestinal epithelium, composed of a single layer of cells, is crucial for preserving gut homeostasis and acts both as a physical barrier and as a coordinating hub for immune defense and crosstalk between bacteria and immune cells VSports手机版. We highlight here recent findings regarding communication between microbes and intestinal epithelial cells (IECs), as well as the immune mechanisms employed by distinct IEC subsets to promote homeostasis, emphasizing the central and active role that these cells play in host enteric defense. .

Keywords: intestinal epithelial cells; microbiota; mucosal immunity V体育安卓版. .

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