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Review
. 2018 Apr 11;10(436):eaap9630.
doi: 10.1126/scitranslmed.aap9630.

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies

Christian Chabannon  1 , Jurgen Kuball  2 , Attilio Bondanza  3 , Francesco Dazzi  4 , Paolo Pedrazzoli  5 , Antoine Toubert  6 , Annalisa Ruggeri  7   8 , Katharina Fleischhauer  9 , Chiara Bonini  10
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Review

Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies (V体育官网)

Christian Chabannon et al. Sci Transl Med. .

Abstract

Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation VSports手机版. .

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