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Randomized Controlled Trial
. 2018 Mar 9;359(6380):1151-1156.
doi: 10.1126/science.aao5774.

"VSports手机版" Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes

Liping Zhao  1   2 , Feng Zhang  3 , Xiaoying Ding  4 , Guojun Wu  3 , Yan Y Lam  2 , Xuejiao Wang  4 , Huaqing Fu  3 , Xinhe Xue  3 , Chunhua Lu  5 , Jilin Ma  5 , Lihua Yu  5 , Chengmei Xu  5 , Zhongying Ren  5 , Ying Xu  6 , Songmei Xu  6 , Hongli Shen  6 , Xiuli Zhu  6 , Yu Shi  7 , Qingyun Shen  7 , Weiping Dong  4 , Rui Liu  3 , Yunxia Ling  4 , Yue Zeng  8 , Xingpeng Wang  8 , Qianpeng Zhang  3 , Jing Wang  3 , Linghua Wang  3 , Yanqiu Wu  3 , Benhua Zeng  9 , Hong Wei  9 , Menghui Zhang  3 , Yongde Peng  10 , Chenhong Zhang  1
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Randomized Controlled Trial

Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes (VSports注册入口)

Liping Zhao et al. Science. .

Abstract

The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, to show that a select group of SCFA-producing strains was promoted by dietary fibers and that most other potential producers were either diminished or unchanged in patients with T2DM VSports手机版. When the fiber-promoted SCFA producers were present in greater diversity and abundance, participants had better improvement in hemoglobin A1c levels, partly via increased glucagon-like peptide-1 production. Promotion of these positive responders diminished producers of metabolically detrimental compounds such as indole and hydrogen sulfide. Targeted restoration of these SCFA producers may present a novel ecological approach for managing T2DM. .

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