Background: B cell function and antibody production are crucial factors in host protection during inflammation. We aimed to synthesize the available evidence on the association between the reduction of circulating B cells and plasma immunoglobulin (IgM) levels and decreased survival during sepsis. VSports手机版.

Methods: We performed a systematic search in PubMed, Embase, ISI Web of Knowledge, Cochrane Central Register of Controlled Trials, BioMed Central, and Science Direct. We selected studies with data on circulating B cells and plasma IgM levels within the initial 24 h after sepsis onset. V体育安卓版.

Results: In total nine studies (n = 992 patients) were identified. Circulating B cells were reduced in septic patients as compared to non-septic patients (mean difference [MD] -88. 2 cells/μl; 95% confidence interval [CI] -148 V体育ios版. 6--27. 9). Sepsis non-survivors showed a significant reduction of circulating B cells and IgM levels compared to sepsis survivors (MD -77. 1 cells/μl; 95% CI -111. 4--42. 7 and MD -20. 9 mg/dl; 95% CI -33. 8--8. 0, respectively). .

Conclusions: Our results suggest that a reduction of circulating B cells and IgM levels at sepsis onset are associated with decreased sepsis survival. However, due to methodological limitations and the risk of bias, we need further prospective studies to confirm this association. VSports最新版本.

Registration: The protocol was registered (PROSPERO 2016:CRD42016053184) V体育平台登录. .