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. 2017 Dec:4:85-89.
doi: 10.1016/j.pvr.2017.10.003. Epub 2017 Oct 19.

V体育平台登录 - Surgical staging identified false HPV-negative cases in a large series of invasive cervical cancers

Karl Ulrich Petry  1 , Clemens Liebrich  2 , Alexander Luyten  2 , Martina Zander  3 , Thomas Iftner  4
Affiliations

Surgical staging identified false HPV-negative cases in a large series of invasive cervical cancers

Karl Ulrich Petry et al. Papillomavirus Res. 2017 Dec.

Abstract

Objective: We examined a large series of biopsy-proven invasive cervical cancers with surgical staging and HPV re-testing to estimate the relevance of HPV-negative cervical cancers in a Caucasian population VSports手机版. .

Methods: We prospectively collected smears from 371 patients with a biopsy-proven diagnosis of cervical cancer for HC2 testing of high-risk HPV (HR-HPV). In HC2-negative cases, smears and paraffin embedded tissue blocks underwent additional HPV genotyping V体育安卓版. .

Results: HC2 tests showed 31/371 cases (8. 8%) had negative findings. Surgical staging showed that 21/31 HC2-negative cases (68%) were not cervical cancer V体育ios版. Overall, 340/350 cases of primary cervical cancer confirmed by surgical staging tested HC2 positive (97. 2%). Non-high-risk HPV subtypes were detected in five cases (one HPV-53, one HPV-70, and three HPV-73) and high-risk subtypes in four patients with HC2-negative cervical cancer (two HPV 16 and two HPV-18). The remaining case, a primary undifferentiated carcinoma of the uterine cervix, tested negative for HPV-DNA with all tests. .

Conclusions: The main explanation for HPV-negative cervical cancer was a false diagnosis, followed by cancers associated with non-HR-HPV types, and false-negative HR-HPV results. Truly HPV negative seem to be very rare in Caucasian populations VSports最新版本. Retrospective analyses without surgical staging may overestimate the proportion of HPV negative cervical cancers. .

Keywords: Adenocarcinoma; Cervical cancer; Diagnosis; HPV-negative. V体育平台登录.

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Figures (VSports最新版本)

Fig. 1
Fig. 1
Flow of patients included in the study. AC = adenocarcinoma, ASC = adenosquamous carcinoma, HC2 = hybrid capture 2; SCC = squamous cell carcinoma.
See this image and copyright information in PMC

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