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Review
. 2017 Oct;17(5):276-286.
doi: 10.4110/in.2017.17.5.276. Epub 2017 Oct 16.

IL-17A-Producing Foxp3+ Regulatory T Cells and Human Diseases

Min Kyung Jung  1 , Jeong-Eun Kwak  2 , Eui-Cheol Shin  1   2
Affiliations
Review

IL-17A-Producing Foxp3+ Regulatory T Cells and Human Diseases

Min Kyung Jung et al. Immune Netw. 2017 Oct.

Abstract

CD4+Foxp3+ regulatory T (Treg) cells play major roles in immune homeostasis. While CD4+Foxp3+ Treg cells act to suppress other immune effector cells, there is growing evidence that they also produce pro-inflammatory cytokines, such as IL-17A, in inflammatory conditions. The pro-inflammatory cytokine milieu, toll-like receptor (TLR) signaling, and specific transcription factors are important for the production of IL-17A by CD4+Foxp3+ Treg cells. In particular, IL-17A-producing CD4+Foxp3+ Treg cells express RORγt, the T helper (Th) 17-specific transcription factor, in addition to Foxp3. IL-17A-producing CD4+Foxp3+ Treg cells are also involved in the pathogenesis of various diseases VSports手机版. Here we review the mechanisms underlying the induction of IL-17A-producing CD4+Foxp3+ Treg cells and the roles of these cells in human disease. .

Keywords: IL-17A; Inflammation; Pro-inflammatory cytokine; Regulatory T-cells. V体育安卓版.

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Conflict of interest statement

Conflict of Interest: The authors declare no potential conflicts of interest.

Figures

Figure 1
Figure 1
IL-17A-producing CD4+FOXP3+ Treg cells in human disease. IL-17A-producing Treg cells express RORγt in addition to Foxp3. They can be induced by pro-inflammatory cytokines and TLR2 signals. Previous findings regarding IL-17A-producing Foxp3+ Treg cells in human disease are summarized. RA, rheumatoid arthritis; HBV, hepatitis B virus.
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