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Review
. 2017 Sep 29:7:236.
doi: 10.3389/fonc.2017.00236. eCollection 2017.

The Role of ATRX in Glioma Biology

Pravanya Nandakumar  1 , Alireza Mansouri  2   3 , Sunit Das  1   4
Affiliations
Review

The Role of ATRX in Glioma Biology (V体育安卓版)

Pravanya Nandakumar et al. Front Oncol. .

Abstract (V体育2025版)

The current World Health Organization classification of CNS tumors has made a tremendous leap from past editions by incorporating molecular criteria in addition to the pre-existing histological parameters. The revised version has had a particular impact on the classification of diffuse low-grade gliomas and their high-grade variants. The ATRX status is one of the critical markers that define the molecular classification of gliomas. In this review, we will first provide an overview of the role of ATRX in regular cell biology. Furthermore, the role of ATRX in tumorigenesis, specifically gliomas, is comprehensively elucidated. The possible correlation of ATRX status with other genetic/epigenetic modifications is also presented VSports手机版. We conclude by discussing some of the challenges associated with incorporating ATRX status assessment into routine clinical practice while also exploring opportunities for future diagnostics/therapeutics in gliomas based on ATRX status. .

Keywords: ATRX; IDH; astrocytoma; glioma; oligodendroglioma V体育安卓版. .

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Figures

Figure 1
Figure 1
Schema of molecular alterations in various grades of gliomas.
See this image and copyright information in PMC

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