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Review
. 2018 Mar;75(6):965-973.
doi: 10.1007/s00018-017-2666-y. Epub 2017 Oct 3.

A double dealing tale of p63: an oncogene or a tumor suppressor

Yonglong Chen  1 , Yougong Peng  2 , Shijie Fan  1 , Yimin Li  1 , Zhi-Xiong Xiao  1 , Chenghua Li  3
Affiliations
Review

A double dealing tale of p63: an oncogene or a tumor suppressor

Yonglong Chen et al. Cell Mol Life Sci. 2018 Mar.

Abstract

As a member of tumor suppressor p53 family, p63, a gene encoding versatile protein variant, has been documented to correlate with cancer formation and progression, though it is rarely mutated in cancer patients. However, it has long been controversial on whether p63 is an oncogene or a tumor suppressor. Here, we comprehensively reviewed reports on roles of p63 in development, tumorigenesis and tumor progression. According to data from molecular cell biology, genetic models and clinic research, we conclude that p63 may act as either an oncogene or a tumor suppressor gene in different scenarios: TA isoforms of p63 gene are generally tumor-suppressive through repressing cell proliferation, survival and metastasis; ΔN isoforms, however, may initiate tumorigenesis via promoting cell proliferation and survival, but inhibit tumor metastasis and progression; effects of p63 on tumor formation and progression depend on the context of the whole p53 family, and either amplification or loss of p63 gene locus can break the balance to cause tumorigenesis. VSports手机版.

Keywords: Cell migration; Cell senescence; Oncoprotein; TAp63; ΔNp63. V体育安卓版.

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Conflict of interest statement

The authors declare no conflict of interest.

V体育平台登录 - Figures

Fig. 1
Fig. 1
Schematic presentation of p63 gene (a) and protein isoforms (b). TAD transactivation domain, TAD2 additional transactivation domain, DBD DNA-binding domain, OD oligomerization domain, SAM sterile alpha motif, TID trans-inhibitory domain. All aliases of each isoforms are listed following the formal terms
Fig. 2
Fig. 2
Roles of p63 in tumor formation, growth and metastasis. TAp63s mainly act as tumor suppressors by inhibiting cell proliferation, survival and tumor metastasis, and occasionally exert oncogenic activity via repressing p53 trans-activity. ΔNp63s promote formation and growth of some epithelium-derived tumors through enhanced cell proliferation and survival. On the other hand, ΔNp63s repress tumor metastasis via inhibition of EMT. A full arrow means a positive regulation, while a blunt arrow represents an inhibition
See this image and copyright information in PMC

References (V体育安卓版)

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