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Review
. 2018 Jan;18(1):35-45.
doi: 10.1038/nri.2017.76. Epub 2017 Aug 7.

"VSports在线直播" Single-cell RNA sequencing to explore immune cell heterogeneity

Efthymia Papalexi  1   2 , Rahul Satija  1   2
Affiliations
Review

"V体育ios版" Single-cell RNA sequencing to explore immune cell heterogeneity

"VSports注册入口" Efthymia Papalexi et al. Nat Rev Immunol. 2018 Jan.

Abstract (V体育安卓版)

Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive analysis of the immune system. In this Review, we briefly describe the available scRNA-seq technologies together with their corresponding strengths and weaknesses. We discuss in depth how scRNA-seq can be used to deconvolve immune system heterogeneity by identifying novel distinct immune cell subsets in health and disease, characterizing stochastic heterogeneity within a cell population and building developmental 'trajectories' for immune cells. Finally, we discuss future directions of the field and present integrated approaches to complement molecular information from a single cell with studies of the environment, epigenetic state and cell lineage. VSports手机版.

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References

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    1. Nucleic Acids Res. 2015 Aug 18;43(14):e93 - VSports app下载 - PubMed
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    1. Cell Stem Cell. 2014 Apr 3;14 (4):486-499 - PubMed

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