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Clinical Trial
. 2017 Sep;96(9):1517-1523.
doi: 10.1007/s00277-017-3069-8. Epub 2017 Jul 21.

"VSports在线直播" Clinical impact of pre-transplant gut microbial diversity on outcomes of allogeneic hematopoietic stem cell transplantation

Noriko Doki  1 , Masahiro Suyama  2   3 , Satoshi Sasajima  3 , Junko Ota  4 , Aiko Igarashi  4 , Iyo Mimura  5 , Hidetoshi Morita  5 , Yuki Fujioka  6   7 , Daisuke Sugiyama  8 , Hiroyoshi Nishikawa  6   8 , Yutaka Shimazu  9 , Wataru Suda  10   11 , Kozue Takeshita  11 , Koji Atarashi  11 , Masahira Hattori  10   12 , Eiichi Sato  13 , Kyoko Watakabe-Inamoto  4 , Kosuke Yoshioka  4 , Yuho Najima  4 , Takeshi Kobayashi  4 , Kazuhiko Kakihana  4 , Naoto Takahashi  7 , Hisashi Sakamaki  4 , Kenya Honda  3   11 , Kazuteru Ohashi  4
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Clinical Trial

Clinical impact of pre-transplant gut microbial diversity on outcomes of allogeneic hematopoietic stem cell transplantation (V体育ios版)

Noriko Doki et al. Ann Hematol. 2017 Sep.

Abstract

Post-transplant microbial diversity in the gastrointestinal tract is closely associated with clinical outcomes following allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, little is known about the impact of the fecal microbiota before allo-HSCT. We analyzed fecal samples approximately 2 weeks before conditioning among 107 allo-HSCT recipients between 2013 and 2015. Microbial analysis was performed using 16S rRNA gene sequencing. Operational taxonomic unit-based microbial diversity was estimated by calculating the Shannon index. Patients were classified into three groups based on the diversity index: low (<2), intermediate (2, 3), and high (>3) diversity (18 (16. 8%), 48 (44. 9%), and 41 (38. 3%) patients, respectively). There were no significant differences in the 20-month overall survival, cumulative incidence of relapse, and non-relapse mortality among three groups. The cumulative incidence of grade II to IV acute graft-versus-host disease (aGVHD) was similar among the three groups (low 55. 6%; intermediate 35. 4%; high 48. 8%, p = 0. 339, at day 100). Furthermore, we found no differences in the cumulative incidence of grade II to IV acute gastrointestinal GVHD among the three groups (low 38. 9%; intermediate 21. 3%; high 24. 4%, p = 0. 778, at day 100). Regarding the composition of microbiota before allo-HSCT, aGVHD patients showed a significantly higher abundance of phylum Firmicutes (p < 0. 01) and a lower tendency for Bacteroidetes (p = 0. 106) than non-aGVHD patients. Maintenance of Bacteroidetes throughout allo-HSCT may be a strategy to prevent aGVHD VSports手机版. .

Keywords: Acute gastrointestinal graft-versus-host disease (GVHD); Allogeneic hematopoietic stem cell transplantation (allo-HSCT); Intestinal microbiota; Microbial diversity V体育安卓版. .

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