Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men (V体育ios版)

Affiliations

Affiliations (V体育官网)

¹ The Kirby Institute, University of New South Wales, Sydney, Australia. Electronic address: mpoynten@qiuluzeuv.cn.
² Regional HPV LabNet Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia; Department of Obstetrics and Gynecology, University of Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia.
³ Department of Obstetrics and Gynecology, University of Melbourne, Victoria, Australia.
⁴ RPA Sexual Health and Central Clinical School, University of Sydney, Sydney, Australia.
⁵ Regional HPV LabNet Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia.
⁶ Melbourne Sexual Health Centre, Alfred Health, Carlton, Melbourne, Victoria, Australia; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
⁷ Department of Obstetrics and Gynecology, University of Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Parkville, Melbourne, Victoria, Australia.
⁸ St Vincent's Hospital, Sydney, Australia.
⁹ St Vincent's Hospital, Sydney, Australia; Western Sydney Sexual Health Centre, University of Sydney, Sydney, Australia.
¹⁰ The Kirby Institute, University of New South Wales, Sydney, Australia.

PMID: 28720461
PMCID: PMC5883229
DOI: 10.1016/j.pvr.2017.02.003

"V体育平台登录" Vaccine-preventable anal human papillomavirus in Australian gay and bisexual men

I Mary Poynten et al. Papillomavirus Res. 2017 Jun.

. 2017 Jun:3:80-84.

doi: 10.1016/j.pvr.2017.02.003. Epub 2017 Feb 21.

Authors

Affiliations (V体育平台登录)

¹ The Kirby Institute, University of New South Wales, Sydney, Australia. Electronic address: mpoynten@qiuluzeuv.cn.
² Regional HPV LabNet Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia; Department of Obstetrics and Gynecology, University of Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia.
³ Department of Obstetrics and Gynecology, University of Melbourne, Victoria, Australia.
⁴ RPA Sexual Health and Central Clinical School, University of Sydney, Sydney, Australia.
⁵ Regional HPV LabNet Reference Laboratory, Department of Microbiology and Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia.
⁶ Melbourne Sexual Health Centre, Alfred Health, Carlton, Melbourne, Victoria, Australia; Central Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.
⁷ Department of Obstetrics and Gynecology, University of Melbourne, Victoria, Australia; Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Microbiology and Infectious Diseases, Royal Women's Hospital, Parkville, Melbourne, Victoria, Australia.
⁸ St Vincent's Hospital, Sydney, Australia.
⁹ St Vincent's Hospital, Sydney, Australia; Western Sydney Sexual Health Centre, University of Sydney, Sydney, Australia.
¹⁰ The Kirby Institute, University of New South Wales, Sydney, Australia.

PMID: 28720461
PMCID: PMC5883229
DOI: 10.1016/j.pvr.2017.02.003

Abstract

Objective: HPV causes ~90% of anal cancer and HPV16 is the type most commonly associated with anal cancer. Gay and bisexual men (GBM) are at greatly increased risk. We investigated patterns of vaccine-preventable anal HPV in older GBM VSports手机版. .

Methods: The Study of the Prevention of Anal Cancer (SPANC) is an ongoing, prospective cohort study of HIV-positive and HIV-negative Australian GBM. Participants completed questionnaires and underwent an anal swab for HPV genotyping using Roche Linear Array. We analysed baseline data from SPANC by HPV type, mean number of types, stratified by age and HIV status. V体育安卓版.

Results: Anal HPV results from 606 (98. 2%) of 617 participants (median age 49 years, 35. 7% HIV-positive) showed 525 (86. 7%) had ≥1 HPV type and 178 (29. 4%) had HPV16. Over one third of participants (214, 35. 3%) had no nonavalent vaccine-preventable types detected V体育ios版. Two (0. 3%) participants had all quadrivalent types and none had all nonavalent vaccine types. HIV-positive participants (p<0. 001) and younger participants (p=0. 059) were more likely to have more vaccine-preventable HPV types detected. .

Conclusion: Anal HPV was highly prevalent in this largely community-based GBM cohort. Vaccine-preventable HPV16 was detected in approximately one third of participants VSports最新版本. These findings suggest that the potential efficacy of HPV vaccination of older GBM should be explored. .

Keywords: Anal; Gay and bisexual men; HIV; HPV; Human papillomavirus; MSM; Prevalence; Vaccine V体育平台登录. .

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Figures

**Fig. 1**
**Prevalence**¹**of vaccine-preventable anal HPV types by HIV status in gay and bisexual men.** 1. 4vHPV=quadrivalent HPV types (HPV6, 11, 16 and 18), 9Vhpv=nonavalent HPV types (HPV6, 11, 16, 18, 31, 33, 45, 52 and 58). 2. HPV31 (p=0.012), HPV52 (p<0.001) and HPV58 (p<0.001) were significantly more prevalent among HIV positive participants. There was not a significant difference in prevalence for HPV16 (p=0.29), HPV18 (p=0.11), HPV33 (p=0.49), HPV45 (p=0.37), HPV6 (p=0.76) and HPV11 (p=0.083) by HIV status.

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References

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