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. 2017 Jul 5;18(7):1441.
doi: 10.3390/ijms18071441.

"VSports" Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer

Chu-Cheng Chang  1   2 , Pei-Ching Lin  3 , Chun-Chi Lin  4   5 , Yuan-Tzu Lan  6   7 , Hung-Hsin Lin  8   9 , Chien-Hsing Lin  10 , Shung-Haur Yang  11   12 , Wen-Yi Liang  13 , Wei-Shone Chen  14   15 , Jeng-Kai Jiang  16   17 , Jen-Kou Lin  18   19 , Shih-Ching Chang  20   21   22
Affiliations

Molecular and Clinicopathological Differences by Age at the Diagnosis of Colorectal Cancer

Chu-Cheng Chang et al. Int J Mol Sci. .

Abstract (VSports注册入口)

We compared the clinicopathological and molecular profiles between different age groups of sporadic colorectal cancer (CRC) patients (age <50, 56-60, 60-70, 70-80, and >80); 1475 CRC patients were enrolled after excluding 30 individuals with Lynch syndrome. The mutation spectra for APC, TP53, KRAS, PIK3CA, FBXW7, BRAF, NRAS, HRAS, TGFbR, Akt1, and PTEN were analyzed using polymerase chain reaction (PCR), followed by MassArray and microsatellite (MSI-high) analysis by performing genotyping. Male patients (74. 1%) were significantly predominant to females (25. 9%) in the older age group (70-80, >80). There was an insignificantly linear trend between TNM staging and age-onset of CRC diagnosis. Patients aged < 50 had 58. 7% diseases in the advanced stages (Stage III: 36. 5% and IV: 22. 2% respectively), while this decreased to 40. 2% (Stage III: 26. 2% and IV; 14 VSports手机版. 0% respectively) in patients >80. The distributions of mutation frequency were similar in majority of the genes studied among different age groups. Additionally, patients aged <50 had significantly higher frequency of MSI-high, PTEN, and HRAS mutations than those of other groups. Age-onset at diagnosis significantly affected overall survival (HR = 1. 46; 95% CI: 1. 35-1. 58), but not cancer-specific survival (HR = 1. 08; 95% CI: 0. 99-1. 18) in multivariate analysis. In conclusion, molecular and clinicopathological differences were not as significant among different age groups of CRC patients as previously suspected. .

Keywords: APC; MSI; PI3K; colorectal cancer; mutation; p53. V体育安卓版.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures (V体育安卓版)

Figure 1
Figure 1
The clinicopathological distributions in different age groups of colorectal cancer patients.
Figure 2
Figure 2
The distributions of molecular alterations in different age groups of colorectal cancer patients.
Figure 3
Figure 3
(A) Cancer-specific survival stratified by different age groups. (p = 0.731m, <50: yellow; 50–60: red; 60–70: gray; 70–89: green; >80: blue). (B) Overall survival stratified by different age groups. (p < 0.001; <50: yellow; 50–60: red; 60–70: gray; 70–89: green; >80: blue).
See this image and copyright information in PMC

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