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. 2017:2017:1930598.
doi: 10.1155/2017/1930598. Epub 2017 May 23.

Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology

Jihan Huang  1   2 , Haitao Tang  3 , Sumin Cao  3 , Yingchun He  1 , Yibin Feng  2 , Kun Wang  1 , Qingshan Zheng  1
Affiliations

Molecular Targets and Associated Potential Pathways of Danlu Capsules in Hyperplasia of Mammary Glands Based on Systems Pharmacology

Jihan Huang et al. Evid Based Complement Alternat Med. 2017.

Abstract

Hyperplasia of mammary glands (HMG) is common in middle-aged women. Danlu capsules (DLCs) can effectively relieve pain and improve clinical symptoms and are safe for treating HMG. However, the active substances in DLCs and the molecular mechanisms of DLCs in HMG remain unclear. This study identified the bioactive compounds and delineated the molecular targets and potential pathways of DLCs by using a systems pharmacology approach. The candidate compounds were retrieved from the traditional Chinese medicine systems pharmacology (TCMSP) database and analysis platform. Each candidate's druggability was analyzed according to its oral bioavailability and drug-likeness indices. The candidate proteins and genes were extracted in the TCMSP and UniProt Knowledgebase, respectively. The potential pathways associated with the genes were identified by performing gene enrichment analysis with DAVID Bioinformatics Resources 6. 7. A total of 603 compounds were obtained from DLCs, and 39 compounds and 66 targets associated with HMG were obtained. Gene enrichment analysis yielded 10 significant pathways with 34 targets. The integrated HMG pathway revealed that DLCs probably act in patients with HMG through multiple mechanisms of anti-inflammation, analgesic effects, and hormonal regulation. This study provides novel insights into the mechanisms of DLCs in HMG, from the molecular level to the pathway level VSports手机版. .

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Figures

Figure 1
Figure 1
GO analysis of therapy targets. The x-axis represents the enrichment scores of these terms (p ≤ 0.05), and the y-axis represents significantly enriched BP categories in GO relative to the targets.
Figure 2
Figure 2
Disease-compound-target network for DLCs. The red, green, and blue nodes represent the disease, compounds, and targets, respectively. The edges represent the interactions among them and nodes sizes are proportional to their degree.
Figure 3
Figure 3
Target-pathway network for HMG. The pink and blue nodes represent the pathway and targets, respectively, and the edges represent the interactions among them.
Figure 4
Figure 4
HMG pathway and therapeutic modules. The distribution of the targets on the compressed HMG pathway. Seven pathways (indicated in different colors) constitute the compressed HMG pathway. The solid and dashed arrows indicate direct and indirect activation, respectively, and the T arrows represent the inhibition effects.
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References

    1. Zhang L.-J., Song A.-F., Wang Z.-H., Lu Y. Effects of the needling method for regulating kidney and smoothing liver on endocrine and immune functions in the patient with hyperplasia of mammary glands. Chinese Acupuncture & Moxibustion. 2008;28(9):648–652. - "V体育ios版" PubMed
    1. Golsteyn E. J., Fritzler M. J. The role of the thymus-hypothalamus-pituitary-gonadal axis in normal immune processes and autoimmunity. Journal of Rheumatology. 1987;14(5):982–990. - PubMed
    1. Fan Y., Pei X., Liu Z., et al. Effectiveness of external Sanjierupi Gao on mastalgia caused by mammary gland hyperplasia: a placebo controlled trial. Journal of Traditional Chinese Medicine. 2013;33(5):603–607. doi: 10.1016/S0254-6272(14)60028-5. - DOI - PubMed
    1. Henry N. L. Endocrine therapy toxicity: management options. American Society of Clinical Oncology Educational Book. 2014;34:e25–e30. doi: 10.14694/EdBook_AM.2014.34.e25. - DOI - PubMed
    1. Qian L.-Q., Pei X.-H., Xu Z.-Y., Wang C. Clinical observation on treatment of hyperplasia of mammary gland by Lirukang Granule. Chinese Journal of Integrative Medicine. 2007;13(2):120–124. doi: 10.1007/s11655-007-0120-y. - DOI - PubMed

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