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. 1985 Apr 6;1(8432):776-8.
doi: 10.1016/s0140-6736(85)91445-x.

Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria (V体育官网入口)

N J White, D A Warrell, S Looareesuwan, P Chanthavanich, R E Phillips, P Pongpaew

V体育2025版 - Pathophysiological and prognostic significance of cerebrospinal-fluid lactate in cerebral malaria

N J White et al. Lancet. .

"VSports" Abstract

Cerebrospinal-fluid (CSF) lactate concentrations were elevated in all but 1 of 45 patients with cerebral malaria. They were significantly higher in patients who died (9. 0 +/- 5. 3 mmol/l, mean +/- SD) than in survivors (3. 4 +/- 1. 1 mmol/l, p = 0. 0002) and had returned to normal values in each of 9 patients studied after recovery of consciousness. There was a significant negative correlation between CSF lactate and CSF glucose. All 11 patients with CSF lactate concentrations above 6 mmol/l died. CSF lactate is thus an important prognostic indicator in cerebral malaria and these findings suggest that hypoxia contributes to the pathogenesis of this disorder VSports手机版. .

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