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. 2017 Apr 14;22(4):632.
doi: 10.3390/molecules22040632.

A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines

Ming Hong  1 , Sha Li  2 , Hor Yue Tan  3 , Fan Cheung  4 , Ning Wang  5 , Jihan Huang  6 , Yibin Feng  7
Affiliations

A Network-Based Pharmacology Study of the Herb-Induced Liver Injury Potential of Traditional Hepatoprotective Chinese Herbal Medicines

Ming Hong et al. Molecules. .

Abstract

Herbal medicines are widely used for treating liver diseases and generally regarded as safe due to their extensive use in Traditional Chinese Medicine practice for thousands of years. However, in recent years, there have been increased concerns regarding the long-term risk of Herb-Induced Liver Injury (HILI) in patients with liver dysfunction. Herein, two representative Chinese herbal medicines: one-Xiao-Chai-Hu-Tang (XCHT)-a composite formula, and the other-Radix Polygoni Multiflori (Heshouwu)-a single herb, were analyzed by network pharmacology study. Based on the network pharmacology framework, we exploited the potential HILI effects of XCHT and Heshouwu by predicting the molecular mechanisms of HILI and identified the potential hepatotoxic ingredients in XCHT and Heshouwu. According to our network results, kaempferol and thymol in XCHT and rhein in Heshouwu exhibit the largest number of liver injury target connections, whereby CASP3, PPARG and MCL1 may be potential liver injury targets for these herbal medicines. This network pharmacology assay might serve as a useful tool to explore the underlying molecular mechanism of HILI. Based on the theoretical predictions, further experimental verification should be performed to validate the accuracy of the predicted interactions between herbal ingredients and protein targets in the future. VSports手机版.

Keywords: Herb-Induced Liver Injury; Radix Polygoni Multiflori; Xiao-Chai-Hu-Tang; hepatoprotective Chinese herbal medicines; network pharmacology. V体育安卓版.

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Conflict of interest statement

The authors declare Jno conflict of interest.

Figures

Figure 1
Figure 1
Compound-target hepatotoxicity network of Xiao chai hu tang. This network represents a global view of the potential compounds (red triangles) and targets (blue rectangles) in XCHT, and it comprised 74 nodes (23 potential compounds and 51 potential targets) and 131 edges (compound-target interactions).
Figure 2
Figure 2
Compound-target network of Heshouwu that are associated with HILI. The red triangles are active compounds from Heshouwu and the blue rectangles represent potential hepatotoxic target genes, the grey lines represent the compound-target interaction. This network comprises 43 nodes (13 candidate compounds and 30 potential targets) and 62 edges (compound-target interactions).
Figure 3
Figure 3
Network pharmacology approach workflow in this study.
See this image and copyright information in PMC

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