年
Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. VSports app下载.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2017 Jan 18;18(1):20.
doi: 10.1186/s12931-017-0505-1.

The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Clara E Green  1 , Alice M Turner  2
Affiliations
Review

"VSports最新版本" The role of the endothelium in asthma and chronic obstructive pulmonary disease (COPD)

Clara E Green et al. Respir Res. .

VSports app下载 - Abstract

COPD and asthma are important chronic inflammatory disorders with a high associated morbidity. Much research has concentrated on the role of inflammatory cells, such as the neutrophil, in these diseases, but relatively little focus has been given to the endothelial tissue, through which inflammatory cells must transmigrate to reach the lung parenchyma and cause damage. There is evidence that there is an abnormal amount of endothelial tissue in COPD and asthma and that this tissue and its' progenitor cells behave in a dysfunctional manner. This article reviews the evidence of the involvement of pulmonary endothelium in COPD and asthma and potential treatment options for this VSports手机版. .

Keywords: Asthma; Chronic bronchitis; Chronic obstructive pulmonary disease; Emphysema; Endothelial dysfunction; Endothelium V体育安卓版. .

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Transendothelial migration (paracellular): Neutrophil passing along the endothelium before binding to an endothelial cell via adhesion molecules (eg MAC-1). The neutrophil invaginates the endothelial cell membrane before migrating between endothelial cells
Fig. 2
Fig. 2
Different endothelial mechanisms important in COPD and asthma pathogenesis
See this image and copyright information in PMC

References

    1. Buist AS, McBurnie MA, Vollmer WM, Gillespie S, Burney P, Mannino DM, et al. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet. 2007;370(9589):741–750. doi: 10.1016/S0140-6736(07)61377-4. - DOI (VSports在线直播) - PubMed
    1. World Health Organisation. Burden of COPD [http://www.who.int/respiratory/copd/burden/en/. Accessed 23 Sep 2016.
    1. Global Initiative for Obstructive Lung Disease [http://www.goldcopd.com. Accessed 23 Sep 2016.
    1. Young RP, Hopkins RJ, Whittington CF, Hay BA, Epton MJ, Gamble GD. Individual and cumulative effects of GWAS susceptibility loci in lung cancer: associations after sub-phenotyping for COPD. PLoS ONE. 2011;6(2):e16476. doi: 10.1371/journal.pone.0016476. - DOI (V体育安卓版) - PMC - PubMed
    1. British Thoracic Society. Scottish Intercollegiate Guidelines Network. SIGN 141: British guideline on the management of asthma 2014 [https://www.brit-thoracic.org.uk/document-library/clinical-information/a.... Accessed 23 Sep 2016.

"V体育2025版" Publication types