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. 2017 Aug;58(8):1859-1871.
doi: 10.1080/10428194.2016.1265113. Epub 2017 Jan 10.

Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant

Jenna D Goldberg  1   2 , Junting Zheng  3 , Ravin Ratan  2 , Trudy N Small  2   4 , Kuan-Chi Lai  1 , Farid Boulad  2   4 , Hugo Castro-Malaspina  1   2 , Sergio A Giralt  1   2 , Ann A Jakubowski  1   2 , Nancy A Kernan  2   4 , Richard J O'Reilly  2   4 , Esperanza B Papadopoulos  1   2 , James W Young  1   2 , Marcel R M van den Brink  1   2 , Glenn Heller  2   3 , Miguel-Angel Perales  1   2
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Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant

VSports - Jenna D Goldberg et al. Leuk Lymphoma. 2017 Aug.

Abstract

Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the effect of poor immune recovery on infection risk is well-established, there are limited data on the effect of immune reconstitution on relapse and survival, especially following T-cell depletion (TCD). To characterize the pattern of immune reconstitution in the first year after transplant and its effects on survival and relapse, we performed a retrospective study in 375 recipients of a myeloablative TCD allo-HSCT for hematologic malignancies. We noted that different subsets recover sequentially, CD8 + T cells first, followed by total CD4 + and naïve CD4 + T cells, indicating thymic recovery during the first year after HSCT. In the multivariate model, a fully HLA-matched donor and recovery of T-cell function, assessed by PHA response at 6 months, were the only factors independently associated with OS and EFS. In conclusion, T-cell recovery is an important predictor of outcome after TCD allo-HSCT VSports手机版. .

Keywords: Immune reconstitution; T-cell depletion; allogeneic hematopoietic stem cell transplant V体育安卓版. .

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Conflict of interest statement

Conflict of Interest Disclosures: The authors report no conflicts of interest.

Figures

Figure 1
Figure 1. Immune recovery for the first 12 months after allo-HSCT with and without ATG
Figure 2
Figure 2. Landmark analysis of immune reconstitution at 6 months on OS and EFS
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References

    1. Small TN, Papadopoulos EB, Boulad F, et al. Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions. Blood. 1999;93:467–480. - PubMed
    1. Maury S, Mary JY, Rabian C, et al. Prolonged immune deficiency following allogeneic stem cell transplantation: risk factors and complications in adult patients. Br J Haematol. 2001;115:630–641. - VSports app下载 - PubMed
    1. Maraninchi D, Gluckman E, Blaise D, et al. Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias. Lancet. 1987;2:175–178. - PubMed
    1. Savani BN, Mielke S, Rezvani K, et al. Absolute lymphocyte count on day 30 is a surrogate for robust hematopoietic recovery and strongly predicts outcome after T cell-depleted allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2007;13:1216–1223. - PMC - PubMed
    1. Powles R, Singhal S, Treleaven J, Kulkarni S, Horton C, Mehta J. Identification of patients who may benefit from prophylactic immunotherapy after bone marrow transplantation for acute myeloid leukemia on the basis of lymphocyte recovery early after transplantation. Blood. 1998;91:3481–3486. - PubMed

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