Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The . gov means it’s official VSports app下载. Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you’re on a federal government site. .

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely V体育官网. .

Review
. 2016 Dec;12(12):731-742.
doi: 10.1038/nrrheum.2016.175. Epub 2016 Oct 27.

Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers (VSports app下载)

Philip M Brown  1 , Arthur G Pratt  1 , John D Isaacs  1
Affiliations
Review

Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers

Philip M Brown et al. Nat Rev Rheumatol. 2016 Dec.

Abstract

The treatment and outcomes of patients with rheumatoid arthritis (RA) have been transformed over the past two decades. Low disease activity and remission are now frequently achieved, and this success is largely the result of the evolution of treatment paradigms and the introduction of new therapeutic agents. Despite the rapid pace of change, the most commonly used drug in RA remains methotrexate, which is considered the anchor drug for this condition. In this Review, we describe the known pharmacokinetic properties and putative mechanisms of action of methotrexate. Consideration of the pharmacodynamic perspective could inform the development of biomarkers of responsiveness to methotrexate, enabling therapy to be targeted to specific groups of patients. Such biomarkers could revolutionize the management of RA. VSports手机版.

PubMed Disclaimer

References

    1. Arthritis Rheum. 2003 Feb;48(2):571-2 - PubMed
    1. Ann Rheum Dis. 2014 Apr;73(4):654-61 - "VSports手机版" PubMed
    1. Ann Rheum Dis. 2013 Jan;72 (1):64-71 - PubMed
    1. Gastroenterology. 1993 Jan;104(1):31-7 - PubMed
    1. J Clin Invest. 1982 Aug;70(2):351-60 - PubMed

VSports注册入口 - Publication types

MeSH terms

V体育官网 - LinkOut - more resources