Aim: Relationships between the intestinal microbiota, intestinal permeability and inflammation in the context of risk for obesity-associated disease continue to be of interest. The aim of the study was to examine the associations between intestinal permeability and type 2 diabetes (T2D). VSports手机版.

Methods: A total of 130 individuals with T2D (age: 57. 5±6. 2 years (mean±SD); BMI: 30. 4±3. 2; 45% female) and 161 individuals without T2D (age: 37. 4±12 V体育安卓版. 5 years; BMI: 25. 1±3. 9; 65% female) were included in the study. Assessment of intestinal permeability included measurement of circulating lipopolysaccharide (LPS), LPS-binding protein (LBP) and intestinal fatty acid binding protein (iFABP) concentrations, which were used for calculation of a derived permeability risk score (PRS). Associations between permeability measures and T2D status were assessed using logistic regression models. .

Results: LBP (∼34%, P<0. 001), iFABP (∼46%, P<0 V体育ios版. 001) and the PRS (∼24% P<0. 001) were all significantly higher in the T2D affected individuals. Individuals with a PRS in the upper tertile were 5. 07 times more likely (CI: 1. 72-14. 95; P=0. 003) to have T2D when models were adjusted for age, sex and BMI. There was a trend towards improved prediction when including the PRS in models containing age, sex and BMI (AUC: 0. 954 versus 0. 962; P=0. 06). .

Conclusion: These data demonstrate differences in measures of intestinal permeability between individuals with and without T2D. The utility of using intestinal permeability measures as a tool for predicting T2D risk in at risk individuals should be further investigated VSports最新版本. .