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. 2017 Apr;31(4):903-912.
doi: 10.1038/leu.2016.281. Epub 2016 Oct 14.

Pre-transplant donor CD4- invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease

M-T Rubio  1   2   3   4   5 , M Bouillié  1   5 , N Bouazza  6 , T Coman  1   5 , H Trebeden-Nègre  7 , A Gomez  2   3   4 , F Suarez  1   5   8 , D Sibon  1   8 , A Brignier  9 , E Paubelle  1   5   8 , S Nguyen-Khoc  10 , M Cavazzana  5   11   12 , O Lantz  13   14 , M Mohty  2   3   4 , S Urien  6   15 , O Hermine  1   5   8
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Pre-transplant donor CD4- invariant NKT cell expansion capacity predicts the occurrence of acute graft-versus-host disease

M-T Rubio et al. Leukemia. 2017 Apr.

"VSports" Abstract

Clinically useful pre-transplant predictive factors of acute graft-versus-host-disease (aGVHD) after allogeneic hematopoietic stem cell transplantation (allo-SCT) are lacking. We prospectively analyzed HSC graft content in CD34+, NK, conventional T, regulatory T and invariant natural killer T (iNKT) cells in 117 adult patients before allo-SCT. Results were correlated with occurrence of aGVHD and relapse. In univariate analysis, iNKT cells were the only graft cell populations associated with occurrence of aGVHD. In multivariate analysis, CD4- iNKT/T cell frequency could predict grade II-IV aGVHD in bone marrow and peripheral blood stem cell (PBSC) grafts, while CD4- iNKT expansion capacity was predictive in PBSC grafts. Receiver operating characteristic analyses determined the CD4- iNKT expansion factor as the best predictive factor of aGVHD. Incidence of grade II-IV aGVHD was reduced in patients receiving a graft with an expansion factor above versus below 6. 83 (9. 7 vs 80%, P<0. 0001), while relapse incidence at two years was similar (P=0. 5). The test reached 94% sensitivity and 100% specificity in the subgroup of patients transplanted with human leukocyte antigen 10/10 PBSCs without active disease. Analysis of this CD4- iNKT expansion capacity test may represent the first diagnostic tool allowing selection of the best donor to avoid severe aGVHD with preserved graft-versus-leukemia effect after peripheral blood allo-SCT. VSports手机版.

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