Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome (VSports在线直播)
- PMID: 27693307
- DOI: 10.1016/j.chom.2016.09.001
Stable Engraftment of Bifidobacterium longum AH1206 in the Human Gut Depends on Individualized Features of the Resident Microbiome
Abstract
Live bacteria (such as probiotics) have long been used to modulate gut microbiota and human physiology, but their colonization is mostly transient. Conceptual understanding of the ecological principles as they apply to exogenously introduced microbes in gut ecosystems is lacking. We find that, when orally administered to humans, Bifidobacterium longum AH1206 stably persists in the gut of 30% of individuals for at least 6 months without causing gastrointestinal symptoms or impacting the composition of the resident gut microbiota. AH1206 engraftment was associated with low abundance of resident B. longum and underrepresentation of specific carbohydrate utilization genes in the pre-treatment microbiome. Thus, phylogenetic limiting and resource availability are two factors that control the niche opportunity for AH1206 colonization. These findings suggest that bacterial species and functional genes absent in the gut microbiome of individual humans can be reestablished, providing opportunities for precise and personalized microbiome reconstitution. VSports手机版.
Keywords: Bifidobacterium; ecological theory; gut microbiome; gut microbiota; invasion ecology; live biotherapeutic; metagenomics; microbial ecology; microbiome modulation; probiotic. V体育安卓版.
Copyright © 2016 Elsevier Inc. All rights reserved V体育ios版. .
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Making It Stick: A Compelling Case for Precision Microbiome Reconstitution.Cell Host Microbe. 2016 Oct 12;20(4):415-417. doi: 10.1016/j.chom.2016.09.012. Cell Host Microbe. 2016. PMID: 27736640
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