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. 2016 Apr 7;127(14):1828-35.
doi: 10.1182/blood-2015-12-688739. Epub 2016 Feb 22.

"VSports注册入口" Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival

Florent Malard  1 , Myriam Labopin  2 , Patrice Chevallier  3 , Thierry Guillaume  3 , Alix Duquesne  4 , Fanny Rialland  3 , Sophie Derenne  4 , Pierre Peterlin  3 , Anne-Gaelle Leauté  4 , Eolia Brissot  5 , Marc Gregoire  6 , Philippe Moreau  3 , Philippe Saas  7 , Béatrice Gaugler  8 , Mohamad Mohty  2
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"VSports在线直播" Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival

Florent Malard et al. Blood. .
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Abstract (VSports在线直播)

We studied the impact of a set of immune cells contained within granulocyte colony-stimulating factor-mobilized peripheral blood stem cell grafts (naïve and memory T-cell subsets, B cells, regulatory T cells, invariant natural killer T cells [iNKTs], NK cells, and dendritic cell subsets) in patients (n = 80) undergoing allogeneic stem cell transplantation (SCT), using the composite end point of graft-versus-host disease (GVHD)-free and progression-free survival (GPFS) as the primary end point. We observed that GPFS incidences in patients receiving iNKT doses above and below the median were 49% vs 22%, respectively (P= . 007). In multivariate analysis, the iNKT dose was the only parameter with a significant impact on GPFS (hazard ratio = 0. 48; 95% confidence interval, 0 VSports手机版. 27-0. 85;P= . 01). The incidences of severe grade III to IV acute GVHD and National Institutes of Health grade 2 to 3 chronic GVHD (12% and 16%, respectively) were low and associated with the use of antithymocyte globulin in 91% of patients. No difference in GVHD incidence was reported according to the iNKT dose. In conclusion, a higher dose of iNKTs within the graft is associated with an improved GPFS. These data may pave the way for prospective and active interventions aiming to manipulate the graft content to improve allo-SCT outcome. .

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