Background: The magnitude of pre-transplant a-fetoprotein (AFP) changes has been advocated to be a superior predictor of hepatocellular cancer (HCC) recurrence following liver transplantation. The aim of this study was to compare AFP dynamics and last pre-transplant AFP as risk factors for post-transplant HCC recurrence. VSports手机版.

Material and methods: Data of 146 patients after liver transplantation for HCC were analyzed retrospectively V体育安卓版. .

Results: While last pre-transplant AFP was a significant predictor of microvascular invasion (p=0. 006) and poor tumor differentiation (p=0. 020), AFP slope was associated only with microvascular invasion (p=0. 029). Notably, last pre-transplant AFP (p<0. 001), but not AFP slope (p=0. 279), was an independent risk factor for recurrence. No significant effects of AFP slope were also found following division of patients into those with pre-transplant AFP <100 (p=0. 260) and those with AFP >100 (p=0. 178) ng/mL. Moreover, prediction of recurrence based on last pre-transplant AFP was superior (p=0. 018) to those based on AFP slope. Recurrence-free survival at 5 years was superior in patients with pre-transplant AFP persistently at (97. 3%) or dropping to <100 ng/mL (100. 0%) as compared to patients with AFP rising to (75. 0%) or persistently at >100 ng/mL (38. 4%; p<0. 001). V体育ios版.

Conclusions: The risk of post-transplant HCC recurrence is dependent on the last pre-transplant AFP regardless of its previous dynamics VSports最新版本. .