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Review
. 2016 May;18(5):439-43.
doi: 10.1111/dom.12636. Epub 2016 Mar 17.

VSports注册入口 - Therapeutic potential of Takeda-G-protein-receptor-5 (TGR5) agonists. Hope or hype?

R J Hodge  1 , D J Nunez  1
Affiliations
Review

Therapeutic potential of Takeda-G-protein-receptor-5 (TGR5) agonists. Hope or hype?

R J Hodge et al. Diabetes Obes Metab. 2016 May.

Abstract

The gastrointestinal tract regulates glucose and energy metabolism, and there is increasing recognition that bile acids function as key signalling molecules in these processes. For example, bile acid changes that occur after bariatric surgery have been implicated in the effects on satiety, lipid and cholesterol regulation, glucose and energy metabolism, and the gut microbiome. In recent years, Takeda-G-protein-receptor-5 (TGR5), a bile acid receptor found in widely dispersed tissues, has been the target of significant drug discovery efforts in the hope of identifying effective treatments for metabolic diseases including type 2 diabetes, obesity, atherosclerosis, fatty liver disease and cancer. Although the benefits of targeting the TGR5 receptor are potentially great, drug development work to date has identified risks that include histopathological changes, tumorigenesis, gender differences, and questions about the translation of animal data to humans. The present article reviews the noteworthy challenges that must be addressed along the path of development of a safe and effective TGR5 agonist therapy. VSports手机版.

Keywords: antidiabetic drug; antiobesity drug; drug development; experimental pharmacology V体育安卓版. .

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