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Review
. 2015 Fall;9(4):1-9.

Zn/Cu Levels in the Field of Autism Disorders: A Systematic Review and Meta-analysis

Fatemeh Sayehmiri  1 , Nasim Babaknejad  1 , Somayeh Bahrami  1 , Kourosh Sayehmiri  2 , Mojtaba Darabi  1 , Mostafa Rezaei-Tavirani  1
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Review

Zn/Cu Levels in the Field of Autism Disorders: A Systematic Review and Meta-analysis

Fatemeh Sayehmiri et al. Iran J Child Neurol. 2015 Fall.

"V体育平台登录" Abstract

Objective: There is probably a relationship between zinc/cupper concentration in individuals with autism VSports手机版. The present review was written to estimate this probability by using meta-analysis method. .

Martials & methods: In this meta-analysis of Fixed Effect Model, by searching PubMed, Scopus and Google scholar databases, 11 articles were selected and verified published in 1978 to 2012. I² statistics were calculated to examine heterogeneity V体育安卓版. The information was analyzed by R and STATA Ver. 11. 2. .

Results: Due to non-uniform measurement methods of Zn/Cu concentrations, the concentration of these elements was measured in various subgroups (plasma, hair and general) in both study cases and controls V体育ios版. There was a significant statistical difference between plasma OR=0. 252 (95% CI: -0. 001-0. 504) and hair OR=0. 27(95% CI: 0. 059-0. 481, P=0. 01) concentrations of Zn/Cu statuses between controls and autistic patients. Using a Fixed Effects Model, the overall integration of data from the two groups was significant as risk factor OR=0. 31(95% CI:0. 16-0. 46, P=0. 001). .

Conclusion: Significant correlation existed between Zn/Cu levels and the development of autistic disorders in general analysis. Therefore, Zn/Cu levels could be mentioned as a pathogenesis reason of autism spectrum disorders. VSports最新版本.

Keywords: Autism spectrum disorders; Concentration; Cupper; Metaanalysis; Zinc V体育平台登录. .

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"VSports app下载" Figures

Fig 1
Fig 1
Study flowchart
Fig 2
Fig 2
Forest plots for the hair and nail Zn/Cu statues difference between autistic patients and healthy individuals. The area of each square is proportional to the percentage weight of each individual study in the meta-analysis (CI 95%). In this chart studies are stored in order of year publication and author’s names, based on a fixed effects model
Fig 3
Fig 3
Forest plots for the plasma Zn/Cu statues difference between autistic patients and healthy individuals. The area of each square is proportional to the percentage weight of each individual study in the meta-analysis (CI 95%). In this chart studies are stored in order of year publication and author’s names, based on a fixed effects model
Fig 4
Fig 4
Forest plots for the studies Zn/Cu statuses combination difference between autistic patients and healthy individuals. The area of each square is proportional to the percentage weight of each individual study in the meta-analysis (CI 95%). In this chart studies are stored in order of year publication and author’s names, based on a random effects model
Fig 5
Fig 5
Sensitivity analyses forest plots for the studies Zn/Cu statuses combination difference between autistic patients and healthy individuals. The area of each square is proportional to the percentage weight of each individual study in the meta-analysis (CI 95%). In this chart, studies are stored in order of year publication and author’s names, based on a fixed effects model
Fig 6.
Fig 6.
Begg’s funnel plot for publication bias in the risk difference (RD) analysis. The diameter of each circle represents the weight in the metaanalysis
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References

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