Background: Segmental distribution of colorectal volume is relevant in a number of diseases, but clinical and experimental use demands robust reliability and validity. Using a novel semi-automatic magnetic resonance imaging-based technique, the aims of this study were to describe: (i) inter-individual and intra-individual variability of segmental colorectal volumes between two observations in healthy subjects and (ii) the change in segmental colorectal volume distribution before and after defecation VSports手机版. .

Methods: The inter-individual and intra-individual variability of four colorectal volumes (cecum/ascending colon, transverse, descending, and rectosigmoid colon) between two observations (separated by 52 ± 10) days was assessed in 25 healthy males and the effect of defecation on segmental colorectal volumes was studied in another seven healthy males V体育安卓版. .

Key results: No significant differences between the two observations were detected for any segments (All p > 0. 05). Inter-individual variability varied across segments from low correlation in cecum/ascending colon (intra-class correlation coefficient [ICC] = 0. 44) to moderate correlation in the descending colon (ICC = 0. 61) and high correlation in the transverse (ICC = 0. 78), rectosigmoid (ICC = 0. 82), and total volume (ICC = 0. 85). Overall intra-individual variability was low (coefficient of variance = 9%) V体育ios版. After defecation the volume of the rectosigmoid decreased by 44% (p = 0. 003). The change in rectosigmoid volume was associated with the true fecal volume (p = 0. 02). .

Conclusions & inferences: Imaging of segmental colorectal volume, morphology, and fecal accumulation is advantageous to conventional methods in its low variability, high spatial resolution, and its absence of contrast-enhancing agents and irradiation. Hence, the method is suitable for future clinical and interventional studies and for characterization of defecation physiology. VSports最新版本.