Background: Genomewide association study (GWAS) published by GABRIEL consortium identified 10 asthma-associated loci. However, their relationship with lung functions is unclear VSports手机版. This study investigated the association between asthma traits and single-nucleotide polymorphisms (SNPs) of these GWAS loci. .

Methods: Rs3894194 and rs9273349 were not genotyped due to unavailable TaqMan assays V体育安卓版. Genetic associations of remaining eight SNPs were investigated in 903 school-age asthmatics and 1205 non-allergic controls. Four significant SNPs were then replicated in 479 adult asthmatics and 746 adult controls, and 1341 Chinese preschool children. Meta-analyses were performed by combining data from school-age children and adults. Generalized multifactor dimensionality reduction (GMDR) was used to analyze their interactions for asthma traits. .

Results: Childhood asthma was associated with GSDMB_rs2305480 (odds ratio [OR] 0. 69, 95% confidence interval [CI] 0. 57-0. 83). IL13_rs1295686 was associated with all asthma (OR 1. 64, 95% CI 1. 16-2. 32) and early-onset asthma (OR 1. 92, 95% CI 1. 20-3 V体育ios版. 06) in adults, whereas GSDMB_rs2305480 was only associated with early-onset asthma (OR 0. 69, 95% CI 0. 49-0. 96). According to meta-analyses, the minor allele of rs2305480 was inversely associated with FEV1 , FVC, and FEV1 /FVC (p < 0. 01). GMDR analyses revealed 2-locus models of SLC22A5 with SMAD3 to modulate FEVt /FVC in both preschool children and adults, with IL13 to determine FVC in both school-age children and adults, and with IL2RB to modulate FEV1 /FVC in school-age children. .

Conclusions: IL13 and GSDMB are replicated as asthma genes. Rs2305480 of GSDMB is also associated with low FEV1 , FVC, and FEV1 /FVC among asthmatics VSports最新版本. Moreover, SLC22A5, IL13, SMAD3, and GSDMB interact to modulate spirometric indices. .