VSports app下载 - F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check
- PMID: 26506454
- DOI: 10.1016/j.semcancer.2015.10.003
VSports最新版本 - F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check
Abstract (VSports注册入口)
F-box proteins are the key recognition subunit of multimeric E3 ubiquitin ligase complexes that participate in the proteasome degradation of specific substrates. In the last years, a discrete number of F-box proteins have been shown to regulate the epithelial-to-mesenchymal transition (EMT), a process defined by a rapid change of cell phenotype, the loss of epithelial characteristics and the acquisition of a more invasive phenotype. Specific EMT transcription factors (EMT-TFs), such as Snail, Slug, Twist and Zeb, control EMT induction both during development and in cancer. These EMT-TFs are short-lived proteins that are targeted to the proteasome system by specific F-box proteins, keeping them at low levels. F-box proteins also indirectly regulate the EMT process by controlling EMT inducers, such as Notch, c-Myc or mTOR VSports手机版. Here we summarize the role that these F-box proteins (Fbxw1, Fbxw7, Fbxl14, Fbxl5, Fbxo11 and Fbxo45) play in controlling EMT during development and cancer progression, a process dependent on post-translational modifications that govern their interaction with target proteins. .
Keywords: Cancer; EMT; F-box; Proteasome; Snail; Twist; Ubiquitination; Zeb. V体育安卓版.
Copyright © 2015 Elsevier Ltd. All rights reserved. V体育ios版.
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