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Multicenter Study
. 2015 Oct 6:8:107.
doi: 10.1186/s13045-015-0207-4.

Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood--a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation

Frédéric Baron  1 , Myriam Labopin  2 , Annalisa Ruggeri  3   4 , Mohamad Mohty  5 , Guillermo Sanz  6 , Noel Milpied  7 , Andrea Bacigalupo  8 , Alessandro Rambaldi  9 , Francesca Bonifazi  10 , Alberto Bosi  11 , Jorge Sierra  12 , Ibrahim Yakoub-Agha  13 , Josep Maria Ribera Santasusana  14 , Eliane Gluckman  15 , Arnon Nagler  16   17
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Multicenter Study

Unrelated cord blood transplantation for adult patients with acute myeloid leukemia: higher incidence of acute graft-versus-host disease and lower survival in male patients transplanted with female unrelated cord blood--a report from Eurocord, the Acute Leukemia Working Party, and the Cord Blood Committee of the Cellular Therapy and Immunobiology Working Party of the European Group for Blood and Marrow Transplantation

Frédéric Baron et al. J Hematol Oncol. .

Abstract

Background: In the setting of allogeneic human leukocyte antigen (HLA)-matched bone marrow transplantation, transplanting male patients with grafts from female donors has been associated with a higher incidence of graft-versus-host disease (GVHD) and of nonrelapse mortality (NRM). The aim of the current analysis was to compare transplantation outcomes in male patients given female unrelated cord blood (UCB) versus other gender combinations VSports手机版. .

Patients and methods: Data from 552 consecutive patients with acute myeloid leukemia (AML) given a single UCB transplantation between 2000 and 2014 were included. V体育安卓版.

Results: In comparison with other gender combination, male patients given female UCB (n = 131) had a trend for a higher incidence of grades II-IV acute GVHD (33 versus 25 %, P = 0. 08), a trend for a higher incidence of NRM (41 versus 33 %, P = 0. 06), and a lower leukemia-free (LFS, 30 versus 41 %, P = 0. 01) and overall survival (OS, 33 versus 45 %, P = 0. 008). In multivariate analyses, taking into consideration all patients for which data on HLA-matching and cell dose transplanted were fully available (n = 363), male patients transplanted with a female UCB had a trend for a higher incidence of grade III-IV acute GVHD (hazard ratio (HR) = 2. 0, P = 0. 06), a trend for a higher NRM (HR = 1. 5, P = 0 V体育ios版. 06), and a worse LFS (HR = 1. 4, P = 0. 04) and OS (HR = 1. 3, P = 0. 06). .

Conclusions: Our data suggest that male patients transplanted with female UCB might have higher risk of acute GVHD and of NRM leading to worse LFS and OS VSports最新版本. These results should be confirmed in other large cohorts of patients before used for determining the choice of an UCB unit. .

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Figures

Fig. 1
Fig. 1
Cumulative incidence of neutrophil engraftment in male patients given female UCB (n = 131) versus in other gender combinations (n = 421)
Fig. 2
Fig. 2
Relapse incidence (a), NRM (b), LFS (c), and overall survival (d) in male patients given female URD (n = 131) versus other gender combinations (n = 421)
Fig. 3
Fig. 3
Relapse incidence (a), NRM (b), LFS (c), and overall survival (d) in male patients given female URD (n = 131) versus in male patients given male UCB (n = 119)
Fig. 4
Fig. 4
Relapse incidence in a landmark analysis selecting patients alive without relapse at 1 year after transplantation (n = 179) and considering chronic GVHD during the first year after transplantation (present in 54 patients)
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References (V体育官网入口)

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